2. Academic Validation
  3. Loss of ID3 drives papillary thyroid cancer metastasis by targeting E47-mediated epithelial to mesenchymal transition

Loss of ID3 drives papillary thyroid cancer metastasis by targeting E47-mediated epithelial to mesenchymal transition

  • Cell Death Discov. 2021 Aug 30;7(1):226. doi: 10.1038/s41420-021-00614-w.
Sunwang Xu  # 1,  Caiqin Mo  # 2,  Junyu Lin  # 2,  Yixing Yan 2,  Xiaoyu Liu 2 3,  Kunlin Wu 2,  Huihao Zhang 2,  Youzhi Zhu 2,  Ling Chen 4,  Xiangjin Chen 5
Affiliations

Affiliations

  • 1 Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. xusw1206@163.com.
  • 2 Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • 3 Department of Thyroid Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.
  • 4 Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. alichoo@163.com.
  • 5 Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. rjbhcxj@fjmu.edu.cn.
  • # Contributed equally.
PMID: 34462424 DOI: 10.1038/s41420-021-00614-w
Abstract

Papillary thyroid Cancer (PTC) is the main histological type of thyroid Cancer and accounts for almost all increased cases worldwide. Patients with PTC exhibit a favorable prognosis, but the fact that PTC is often accompanied by a high prevalence of lymph node metastasis (LNM) means that the overall recurrence-free survival rate in PTC patients is relatively low. Herein, we identified that ID3 expression is subdued in PTC tissues and closely associated with LNM and a poor disease-free survival outcome in PTC patients. The main contributor to this gene repression is the hypermethylation of the CpG island at the promoter of ID3. Besides, we uncovered that a loss of ID3 promotes invasion and migration of PTC cells, while an ectopic overexpression of ID3 inhibits invasion and migration. Mechanistically, ID3 exhibits tumor suppressor functions in PTC cells by interacting with E47 to form heterodimers that prevent E47 binding to CDH1 promoter and maintaining CDH1 transcription and epithelial phenotype in PTC cells. Taken together, our study demonstrates that ID3 plays a tumor suppressor role in PTC and impedes metastasis by inhibiting E47-mediated epithelial to mesenchymal transition.

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