2. Academic Validation
  3. Salicinoyl Quinic Acids and Their Prostaglandin E2 Production Inhibitory Activities from the Fruits of Casearia grewiifolia

Salicinoyl Quinic Acids and Their Prostaglandin E2 Production Inhibitory Activities from the Fruits of Casearia grewiifolia

  • J Nat Prod. 2021 Sep 24;84(9):2437-2446. doi: 10.1021/acs.jnatprod.1c00343.
Piseth Nhoek 1,  Sungjin Ahn 2,  In Guk Park 2,  Pisey Pel 2,  Jungmoo Huh 2,  Hyun Woo Kim 2,  Jongmin Ahn 2,  Piseth Khiev 3,  Young Hee Choi 1,  Kyeong Lee 1,  Minsoo Noh 2,  Young-Won Chin 2
Affiliations

Affiliations

  • 1 College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do 10326, Republic of Korea.
  • 2 College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
  • 3 Department of Biology, Royal University of Phnom Penh, Russian Federation Boulevard, Khan Toul Kork, Phnom Penh 12156, Cambodia.
PMID: 34463498 DOI: 10.1021/acs.jnatprod.1c00343
Abstract

Phytochemical investigation on the dried fruits of Casearia grewiifolia led to the identification of 10 new salicinoyl quinic acid derivatives (1-10), a new benzoyl quinic acid (11), and two known compounds (12 and 13). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E2 (PGE2) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE2 production with IC50 values of 20.5 and 28.8 μM, respectively.

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