2. Academic Validation
  3. Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19

Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19

  • ACS Nano. 2021 Sep 28;15(9):14347-14359. doi: 10.1021/acsnano.1c03252.
Yue Yin 1,  Wen Su 1,  Jie Zhang 1,  Wenping Huang 1,  Xiaoyang Li 1 2,  Haixia Ma 1,  Mixiao Tan 1,  Haohao Song 1,  Guoliang Cao 1,  Shengji Yu 2,  Di Yu 3,  Ji Hoon Jeong 4,  Xiao Zhao 1,  Hui Li 5,  Guangjun Nie 1 6,  Hai Wang 1 6
Affiliations

Affiliations

  • 1 CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
  • 2 Department of Orthopedics, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
  • 3 Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, 75185, Sweden.
  • 4 School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • 5 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China.
  • 6 University of Chinese Academy of Sciences, Beijing, 100049, China.
PMID: 34472328 DOI: 10.1021/acsnano.1c03252
Abstract

The successful control of coronavirus disease 2019 (COVID-19) pandemic is not only relying on the development of vaccines, but also depending on the storage, transportation, and administration of vaccines. Ideally, nucleic acid vaccine should be directly delivered to proper immune cells or tissue (such as lymph nodes). However, current developed vaccines are normally treated through intramuscular injection, where immune cells do not normally reside. Meanwhile, current nucleic acid vaccines must be stored in a frozen state that may hinder their application in developing countries. Here, we report a separable microneedle (SMN) patch to deliver polymer encapsulated spike (or nucleocapsid) protein encoding DNA vaccines and immune Adjuvant for efficient immunization. Compared with intramuscular injection, SMN patch can deliver nanovaccines into intradermal for inducing potent and durable adaptive immunity. IFN-γ+CD4/8+ and IL-2+CD4/8+ T cells or virus specific IgG are significantly increased after vaccination. Moreover, in vivo results show the SMN patches can be stored at room temperature for at least 30 days without decreases in immune responses. These features of nanovaccines-laden SMN patch are important for developing advanced COVID-19 vaccines with global accessibility.

Keywords

COVID-19; DNA vaccines; adaptive immunity; immune adjuvant; separable microneedle.

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