2. Academic Validation
  3. The Control of Rat Hippocampal Gamma Oscillation Strength by BK Channel Activity

The Control of Rat Hippocampal Gamma Oscillation Strength by BK Channel Activity

  • Neuroscience. 2021 Nov 1;475:220-228. doi: 10.1016/j.neuroscience.2021.09.002.
Yujiao Zhang 1,  Zhenyi Li 2,  Yinghua Zhang 3,  Hongxing Zhang 4,  Chengbiao Lu 5,  Martin Vreugdenhil 6
Affiliations

Affiliations

  • 1 Institute of Acupuncture and Moxibustion, Chinese Medicine Innovation Research Institute, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China; School of Psychology, Xinxiang Medical University, Xinxiang, Henan 453003, China. Electronic address: zyj-103@163.com.
  • 2 Department of Psychological Counseling, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China; School of Psychology, Xinxiang Medical University, Xinxiang, Henan 453003, China.
  • 3 Department of Human Anatomy & Histoembryology, School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan 453003, China.
  • 4 School of Psychology, Xinxiang Medical University, Xinxiang, Henan 453003, China.
  • 5 International-Joint Lab for Neural Modulation of Henan Province/Key Laboratory for the Brain Research of Henan Province, Department of Physiology and Pathology, School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan 453003, China. Electronic address: johnlu9000@163.com.
  • 6 Department of Life Science, School of Health Sciences, Birmingham City University, Westbourne Road, Birmingham B15 3TN, United Kingdom. Electronic address: martin.vreugdenhil@bcu.ac.uk.
PMID: 34509547 DOI: 10.1016/j.neuroscience.2021.09.002
Abstract

Neuronal network oscillations in the gamma frequency band (30-80 Hz, γ oscillations) are associated with the higher brain functions such as perception, attention, learning and memory. BK channels mediate rapid repolarization and fast afterhyperpolarization in neurons and control neuronal excitability, and potentially control hippocampal γ oscillations. In this study, we examined the effects of modulating BK channels on hippocampal γ oscillations in the absence or presence of CA2+ influx through voltage-gated CA2+ channels (VGCC) or CA2+-permeable AMPA receptors (CP-AMPAR). We found that blocking BK channels enhanced γ power, without affecting oscillation frequency or regularity, suggesting that BK channel activity suppresses γ oscillations. Blocking either VGCC or CP-AMPAR itself enhanced γ power, and completely occluded the effect of BK channel blockers on γ oscillations, whereas blocking BK channels first could not prevent a further γ power increase upon blockade of either CP-AMPAR or VGCC. We propose that CA2+ influx through VGCC or CP-AMPAR during γ oscillations, cause membrane BK channel activation and regulate hippocampal γ oscillation strength by negative feedback.

Keywords

BK channels; CA3; CP-AMPAR; VGCC; gamma oscillations.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z