2. Academic Validation
  3. 2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene

2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene

  • Xenobiotica. 2022 Apr;52(4):360-369. doi: 10.1080/00498254.2022.2079022.
Kunna Li 1 2,  Ying Zou 1 2,  Yang Wang 1 2,  Mengyue Zhou 1 2,  Jing Li 1 2,  Rong Tan 1 2,  Shiyu Zhang 1 2,  Weiwei Li 1 2,  Jiang Zheng 1 2 3 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, P R China.
  • 2 School of Pharmacy, Guizhou Medical University, Guiyang, P R China.
  • 3 Key Laboratory of Environmental Pollution, Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, P R China.
  • 4 Wuya of Innovation, Shenyang Pharmaceutical University, Shenyang, P R China.
PMID: 35575452 DOI: 10.1080/00498254.2022.2079022
Abstract

2-Methylnaphthalene (2-MN) is an environmental pollutant. Studies have shown that 2-MN is teratogenic, carcinogenic, and cytotoxic. However, the mechanisms of 2-MN induced toxicities remain unclear.This study aimed to characterise reactive metabolites of 2-MN, to define the metabolic pathway, and to determine the Enzymes participating in the metabolic activation.A hydroxylation metabolite of 2-MN, 2-naphthalenemethanol (2-NM), was observed in 2-MN-containing mouse liver microsomes.A glutathione (GSH) conjugate was detected in mouse S9 incubations fortified with 2-MN and GSH. A GSH conjugate and an NAC conjugate were found in mouse liver and urine, respectively, in Animals given 2-MN. Hepatic protein covalent binding derived from 2-NM was observed in Animals administered 2-MN.Cytochrome P450 enzymes and sulfotransferases participated in the metabolic activation of 2-MN.

Keywords

2-methylnaphthalene; 2-naphthalenemethanol; P450 enzymes; metabolic activation; sulfotransferases.

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