2. Academic Validation
  3. Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism

Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism

  • Biochem Pharmacol. 2022 Aug;202:115101. doi: 10.1016/j.bcp.2022.115101.
Bo Zhang 1,  Rongzhan Fu 1,  Zhiguang Duan 1,  Shihong Shen 1,  Chenhui Zhu 2,  Daidi Fan 3
Affiliations

Affiliations

  • 1 Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China; Biotech. & Biomed. Research Institute, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
  • 2 Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China; Biotech. & Biomed. Research Institute, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China. Electronic address: zch2005@nwu.edu.cn.
  • 3 Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China; Biotech. & Biomed. Research Institute, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China. Electronic address: fandaidi@nwu.edu.cn.
PMID: 35618001 DOI: 10.1016/j.bcp.2022.115101
Abstract

Breast Cancer (BC) has replaced lung Cancer as the most common Cancer worldwide. Ginsenoside CK (CK) can effectively inhibit triple-negative breast Cancer (TNBC), the occurrence and development of which are associated with glutamine addiction. However, the connection between CK and glutamine metabolism in TNBC proliferation and the mechanism of cell death induction remains unclear. Here, we found that high glutamine-addicted TNBC cells were particularly sensitive to CK treatment. CK exerted antitumour activity against TNBC by suppressing glutamine consumption and glutamate production via downregulation of Glutaminase 1 (GLS1) expression. CK treatment further decreased cellular ATP production, reduced the utilisation of Amino acids associated with glutamine metabolism, and induced glutathione (GSH) depletion and Reactive Oxygen Species (ROS) accumulation, consequently triggering Apoptosis in TNBC. Furthermore, CK decreased GLS1 expression in SUM159 xenograft mouse mammary tumours and significantly inhibited tumour growth with few side effects. Together, our data provide a powerful theoretical basis for the application of CK as a glutamine metabolic inhibitor in TNBC treatment.

Keywords

Apoptosis; GLS1; Ginsenoside CK; Glutamine metabolism; Triple-negative breast cancer.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z