2. Academic Validation
  3. Long wavelength-emissive Ru(II) metallacycle-based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment

Long wavelength-emissive Ru(II) metallacycle-based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment

  • Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2209904119. doi: 10.1073/pnas.2209904119.
Yuling Xu 1,  Chonglu Li 1,  Xin Ma 1,  Wei Tuo 2,  Le Tu 3,  Xiaopeng Li 4,  Yan Sun 2 5,  Peter J Stang 2,  Yao Sun 1
Affiliations

Affiliations

  • 1 Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
  • 2 Department of Chemistry, University of Utah, Salt Lake City, UT 84112.
  • 3 Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecular, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.
  • 4 College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.
  • 5 Ministry of Education Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, China.
PMID: 35914164 DOI: 10.1073/pnas.2209904119
Abstract

Ruthenium (Ru) complexes are developed as latent emissive photosensitizers for Cancer and pathogen photodiagnosis and therapy. Nevertheless, most existing Ru complexes are limited as photosensitizers in terms of short excitation and emission wavelengths. Herein, we present an emissive Ru(II) metallacycle (herein referred to as 1) that is excited by 808-nm laser and emits at a wavelength of ∼1,000 nm via coordination-driven self-assembly. Metallacycle 1 exhibits good optical penetration (∼7 mm) and satisfactory Reactive Oxygen Species production properties. Furthermore, 1 shows broad-spectrum Antibacterial activity (including against drug-resistant Escherichia coli) as well as low cytotoxicity to normal mammalian cells. In vivo studies reveal that 1 is employed in precise, second near-infrared biomedical window fluorescent imaging-guided, photo-triggered treatments in Staphylococcus aureus-infected mice models, with negligible side effects. This work thus broads the applications of supramolecular photosensitizers through the strategy of lengthening their wavelengths.

Keywords

long-wavelength emissive; metallacycle; supramolecular coordination complexes.

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