2. Academic Validation
  3. The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling

The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling

  • Nat Commun. 2022 Aug 9;13(1):4680. doi: 10.1038/s41467-022-32472-0.
Huanhuan Cui 1 2 3,  Hongyang Yi  # 4,  Hongyu Bao  # 4 5,  Ying Tan  # 4,  Chi Tian  # 4,  Xinyao Shi 4,  Diwen Gan 4,  Bin Zhang 6,  Weizheng Liang 4,  Rui Chen 4,  Qionghua Zhu 7 4,  Liang Fang 7 4 8,  Xin Gao 6,  Hongda Huang 4 5,  Ruijun Tian 9,  Silke R Sperling 10,  Yuhui Hu 7 4,  Wei Chen 11 12 13
Affiliations

Affiliations

  • 1 Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China. cuihh@sustech.edu.cn.
  • 2 Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China. cuihh@sustech.edu.cn.
  • 3 Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, 518005, China. cuihh@sustech.edu.cn.
  • 4 Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
  • 5 Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
  • 6 Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
  • 7 Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
  • 8 Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, 518005, China.
  • 9 Department of Chemistry, School of Science, Southern University of Science and Technology, Shenzhen, 518005, China.
  • 10 Cardiovascular Genetics, Charité-Universitätsmedizin Berlin, 13125, Berlin, Germany.
  • 11 Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China. chenw@sustech.edu.cn.
  • 12 Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China. chenw@sustech.edu.cn.
  • 13 Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, 518005, China. chenw@sustech.edu.cn.
  • # Contributed equally.
PMID: 35945219 DOI: 10.1038/s41467-022-32472-0
Abstract

DPF3, a component of the SWI/SNF chromatin remodeling complex, has been associated with clear cell renal cell carcinoma (ccRCC) in a genome-wide association study. However, the functional role of DPF3 in ccRCC development and progression remains unknown. In this study, we demonstrate that DPF3a, the short isoform of DPF3, promotes kidney Cancer cell migration both in vitro and in vivo, consistent with the clinical observation that DPF3a is significantly upregulated in ccRCC patients with metastases. Mechanistically, DPF3a specifically interacts with SNIP1, via which it forms a complex with SMAD4 and p300 Histone Acetyltransferase (HAT), the major transcriptional regulators of TGF-β signaling pathway. Moreover, the binding of DPF3a releases the repressive effect of SNIP1 on p300 HAT activity, leading to the increase in local histone acetylation and the activation of cell movement related genes. Overall, our findings reveal a metastasis-promoting function of DPF3, and further establish the link between SWI/SNF components and ccRCC.

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