2. Academic Validation
  3. Targeted Isolation of Anti-inflammatory Lignans from Justicia aequilabris by Molecular Networking Approach

Targeted Isolation of Anti-inflammatory Lignans from Justicia aequilabris by Molecular Networking Approach

  • J Nat Prod. 2022 Sep 23;85(9):2184-2191. doi: 10.1021/acs.jnatprod.2c00478.
Joanda P R E Silva 1,  Laiane C O Pereira 1,  Lucas S Abreu 2,  Francisca S V Lins 1,  Thalisson A de Souza 1,  Renan F do Espírito-Santo 3,  Renata P C Barros 1,  Cristiane F Villarreal 4,  José I M de Melo 1,  Marcus T Scotti 1,  Vicente C de O Costa 1,  Lucas H Martorano 2,  Fernando M Dos Santos Jr 2,  Raimundo Braz Filho 5,  Marcelo S da Silva 1,  Josean F Tavares 1
Affiliations

Affiliations

  • 1 Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58037, Brazil.
  • 2 Department of Chemistry, Institute of Chemistry, Fluminense Federal University, Niterói 24220-008, Brazil.
  • 3 Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 40015, Brazil.
  • 4 School of Pharmacy, Federal University of Bahia, Salvador 41500-290, Brazil.
  • 5 Department of Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23890, Brazil.
PMID: 35998343 DOI: 10.1021/acs.jnatprod.2c00478
Abstract

Herein, the isolation of secondary metabolites from the aerial parts of Justicia aequilabris guided by HPLC-MSn and molecular networking analyses is reported. Twenty-two known compounds were dereplicated. Three new Lignans (aequilabrines A-C (1-3)) and three known compounds (lariciresinol-4'-O-β-glucose (4), roseoside (5), and allantoin (6)) were obtained. The anti-inflammatory activity of compounds 1-3 was evaluated in vitro by inhibiting the nitric oxide production (NO) and pro-inflammatory activity on the cytokine IL-1β. Compounds 2 and 3 showed significant inhibitory activity against NO production, with IC50 values of 9.1 and 7.3 μM, respectively. The maximum inhibition of IL-1β production was 23.5% (1), 27.3% (2), and 32.5% (3).

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