Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia

Affiliations

• 1 Academy for Advanced Interdisciplinary Studies, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China.
• 2 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou, 510632, China.
• 3 Cryo-EM Center, Southern University of Science and Technology, Shenzhen, 518055, China.
• 4 State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, 999078, China. Electronic address: qwzhang@um.edu.mo.
• 5 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou, 510632, China. Electronic address: zzmoxue@163.com.
• 6 Academy for Advanced Interdisciplinary Studies, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China. Electronic address: liyj@sustech.edu.cn.
• 7 Academy for Advanced Interdisciplinary Studies, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, and Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, 518000, China; Shenzhen Bay Laboratory, Shenzhen, 518132, China. Electronic address: zhangxm@sustech.edu.cn.