2. Academic Validation
  3. Anti-Epstein-Barr Viral Agents from the Medicinal Herb-Derived Fungus Alternaria alstroemeriae Km2286

Anti-Epstein-Barr Viral Agents from the Medicinal Herb-Derived Fungus Alternaria alstroemeriae Km2286

  • J Nat Prod. 2022 Nov 25;85(11):2667-2674. doi: 10.1021/acs.jnatprod.2c00783.
Chia-Hao Chang 1,  Yi-Chieh Lee 1,  George Hsiao 2 3,  Li-Kwan Chang 4,  Wei-Chiung Chi 5,  Yuan-Chung Cheng 6,  Shu-Jung Huang 1,  Tai-Chou Wang 7,  Yi-Shan Lu 4,  Tzong-Huei Lee 1
Affiliations

Affiliations

  • 1 Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan.
  • 2 Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
  • 3 Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
  • 4 Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan.
  • 5 Department of Food Science, National Quemoy University, Kinmen 89250, Taiwan.
  • 6 Department of Chemistry and Center for Quantum Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
  • 7 Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
PMID: 36346918 DOI: 10.1021/acs.jnatprod.2c00783
Abstract

Chromatographic separation on the liquid-state fermented products produced by the Fungal strain Alternaria alstroemeriae Km2286 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1-9. Structures were determined by spectroscopic analysis as four undescribed perylenequinones, altertromins A-D (1-4), along with altertoxin IV (5), altertoxin VIII (6), stemphyperylenol (7), tenuazonic acid (8), and allo-tenuazonic acid (9). Compounds 1-6 exhibited Antiviral activities against Epstein-Barr virus (EBV) with EC50 values ranging from 0.17 ± 0.07 to 3.13 ± 0.31 μM and selectivity indices higher than 10. In an anti-neuroinflammatory assay, compounds 1-4, 6, and 7 showed inhibitory activity of nitric oxide production in lipopolysaccharide-induced microglial BV-2 cells, with IC50 values ranging from 0.33 ± 0.04 to 4.08 ± 0.53 μM without significant cytotoxicity. This is the first report to describe perylenequinone-type compounds with potent anti-EBV and anti-neuroinflammatory activities.

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