Discovery of pan-IAP degraders via a CRBN recruiting mechanism

Affiliations

• 1 Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, 34141, South Korea.
• 2 Data Convergence Drug Research Center, Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, South Korea.
• 3 Data Convergence Drug Research Center, Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, South Korea; Department of New Drug Discovery and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 305-764, South Korea.
• 4 Critical Diseases Diagnostics Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, 34141, South Korea; Department of Proteome Structural Biology, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, South Korea.
• 5 Core Research Facility & Analysis Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, 34141, South Korea; College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, 28160, South Korea.
• 6 Core Research Facility & Analysis Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, 34141, South Korea.
• 7 Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, 34141, South Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, South Korea; Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, South Korea.
• 8 Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, 34141, South Korea; Department of New Drug Discovery and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 305-764, South Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, South Korea. Electronic address: jhoonkim@kribb.re.kr.
• 9 Data Convergence Drug Research Center, Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, South Korea; Department of New Drug Discovery and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 305-764, South Korea. Electronic address: hyunjin@krict.re.kr.