2. Academic Validation
  3. Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma

Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma

  • Int J Mol Sci. 2022 Nov 28;23(23):14909. doi: 10.3390/ijms232314909.
Ji-Won Park 1,  Jinseon Choi 1 2,  Juhyun Lee 1 3,  Jin-Mi Park 1 2,  Seong-Man Kim 1,  Jae-Hong Min 4,  Da-Yun Seo 1 2,  Soo-Hyeon Goo 1,  Ju-Hee Kim 1,  Ok-Kyoung Kwon 1 5,  Kihoon Lee 6,  Kyung-Seop Ahn 1,  Sei-Ryang Oh 1 5,  Jae-Won Lee 1
Affiliations

Affiliations

  • 1 Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea.
  • 2 College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
  • 3 College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
  • 4 Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong Health Technology Administration Complex, Cheongju 28159, Republic of Korea.
  • 5 Natural Product Central Bank, Korea Research Institute of Bioscience and Biotechnology, Cheonju 28116, Republic of Korea.
  • 6 Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea.
PMID: 36499236 DOI: 10.3390/ijms232314909
Abstract

Methyl p-coumarate (methyl p-hydroxycinnamate) (MH) is a natural compound found in a variety of Plants. In the present study, we evaluated the ameliorative effects of MH on airway inflammation in an experimental model of allergic asthma (AA). In this in vitro study, MH was found to exert anti-inflammatory activity on PMA-stimulated A549 airway epithelial cells by suppressing the secretion of IL-6, IL-8, MCP-1, and ICAM-1. In addition, MH exerted an inhibitory effect not only on NF-κB (p-NF-κB and p-IκB) and AP-1 (p-c-Fos and p-c-Jun) activation but also on A549 cell and EOL-1 cell (eosinophil cell lines) adhesion. In LPS-stimulated RAW264.7 macrophages, MH had an inhibitory effect on TNF-α, IL-1β, IL-6, and MCP-1. The results from in vivo study revealed that the increases in eosinophils/Th2 cytokines/MCP-1 in the bronchoalveolar lavage fluid (BALF) and IgE in the serum of OVA-induced mice with AA were effectively inhibited by MH administration. MH also exerted a reductive effect on the immune cell influx, mucus secretion, and iNOS/COX-2 expression in the lungs of mice with AA. The effects of MH were accompanied by the inactivation of NF-κB. Collectively, the findings of the present study indicated that MH attenuates airway inflammation in mice with AA, suggesting its potential as an Adjuvant in asthma therapy.

Keywords

NF-κB; Th2 cytokines; asthma; eosinophil; methyl p-coumarate.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z