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  3. Multi-omics profiling visualizes dynamics of cardiac development and functions

Multi-omics profiling visualizes dynamics of cardiac development and functions

  • Cell Rep. 2022 Dec 27;41(13):111891. doi: 10.1016/j.celrep.2022.111891.
Yayun Gu 1,  Yan Zhou 1,  Sihan Ju 2,  Xiaofei Liu 3,  Zicheng Zhang 3,  Jia Guo 3,  Jimiao Gao 1,  Jie Zang 4,  Hao Sun 3,  Qi Chen 1,  Jinghan Wang 1,  Jiani Xu 4,  Yiqun Xu 1,  Yingjia Chen 3,  Yueshuai Guo 3,  Juncheng Dai 1,  Hongxia Ma 1,  Cheng Wang 3,  Guangfu Jin 1,  Chaojun Li 3,  Yankai Xia 1,  Hongbing Shen 1,  Yang Yang 3,  Xuejiang Guo 3,  Zhibin Hu 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211100, China; School of Public Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu 211100, China.
  • 2 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211100, China; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
  • 3 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211100, China.
  • 4 School of Public Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu 211100, China.
  • 5 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211100, China; School of Public Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu 211100, China. Electronic address: zhibin_hu@njmu.edu.cn.
PMID: 36577384 DOI: 10.1016/j.celrep.2022.111891
Abstract

Cardiogenesis is a tightly regulated dynamic process through a continuum of differentiation and proliferation events. Key factors and pathways governing this process remain incompletely understood. Here, we investigate mice hearts from embryonic day 10.5 to postnatal week 8 and dissect developmental changes in phosphoproteome-, proteome-, metabolome-, and transcriptome-encompassing cardiogenesis and cardiac maturation. We identify mitogen-activated protein kinases as core kinases involved in transcriptional regulation by mediating the phosphorylation of chromatin remodeling proteins during early cardiogenesis. We construct the reciprocal regulatory network of transcription factors (TFs) and identify a series of TFs controlling early cardiogenesis involved in cycling-dependent proliferation. After birth, we identify cardiac resident macrophages with high arachidonic acid metabolism activities likely involved in the clearance of injured apoptotic cardiomyocytes. Together, our comprehensive multi-omics data offer a panoramic view of cardiac development and maturation that provides a resource for further in-depth functional exploration.

Keywords

CP: Developmental biology; cardiac maturation; cardiogenesis; efferocytosis; macrophages; multi-omics; protein phosphorylation; transcriptional regulation.

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