2. Academic Validation
  3. A novel circular RNA circNLRP3 alleviated ricin toxin-induced TNF-α production through sponging miR-221-5p

A novel circular RNA circNLRP3 alleviated ricin toxin-induced TNF-α production through sponging miR-221-5p

  • Toxicon. 2023 Jan 23;224:107046. doi: 10.1016/j.toxicon.2023.107046.
Wei Chen 1,  Ying Chang 2,  Chengbiao Sun 3,  Meng Xu 4,  Mingxin Dong 3,  Na Zhao 3,  Yan Wang 3,  Jianxu Zhang 3,  Na Xu 5,  Wensen Liu 6
Affiliations

Affiliations

  • 1 Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji, 133002, Jilin, PR China.
  • 2 Jilin Medical University, Jilin, 132013, Jilin, PR China.
  • 3 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, Jilin, PR China.
  • 4 College of Life Science, Jilin Agricultural University, Changchun, 130118, Jilin, PR China.
  • 5 Jilin Medical University, Jilin, 132013, Jilin, PR China. Electronic address: xunajlu@sina.com.
  • 6 Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji, 133002, Jilin, PR China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, Jilin, PR China. Electronic address: liuws85952@163.com.
PMID: 36702354 DOI: 10.1016/j.toxicon.2023.107046
Abstract

Acting as MicroRNA (miRNA) sponges, circular RNAs (circRNAs) have been discovered to be critical modulators of inflammatory processes. Ricin Toxin (RT) is highly toxic to mammalian cells and low doses of RT can induce acute inflammation. However, current researches on the underlying mechanism and function of circRNA/miRNA network in RT-induced inflammation are limited. Previously, we found miR-221-5p was aberrant and associated with the inflammation of RT induction. In this study, based on the circRNA high-throughput Sequencing (circRNA-seq), we obtained a novel circRNA termed circNLRP3 and revealed that circNLRP3 can Sponge miR-221-5p, release its target mRNA A20, and further suppress NF-κB signaling pathway to alleviated RT-induced TNF-α production. Our findings elucidated a possible mechanistic link between the circNLRP3/miR-221-5p/A20 axis and RT-induced inflammatory response, which may broaden our understanding of RT poisoning.

Keywords

CircNLRP3; MiR-221–5p; Ricin toxin; TNF-α.

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