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  3. Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion

Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion

  • Int J Mol Sci. 2023 Feb 6;24(4):3179. doi: 10.3390/ijms24043179.
Songyun Deng 1 2,  Mankai Yang 1 2,  Jianwen Su 1 2,  Naiqian Cui 1 2,  Siyuan Wu 1 2,  Guangyan Zhang 1 2,  Lei Wang 1 2,  Yilong Hou 1 2,  Yu Chai 1 2,  Bin Yu 1 2
Affiliations

Affiliations

  • 1 Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • 2 Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
PMID: 36834587 DOI: 10.3390/ijms24043179
Abstract

The mechanism of systemic osteoporosis caused by chronic Infection is not completely clear, and there is a lack of reasonable interventions for this disease. In this study, heat-killed S. aureus (HKSA) was applied to simulate the inflammation caused by the typical clinical pathogen and to explore the mechanism of systemic bone loss caused by it. In this study, we found that the systemic application of HKSA caused bone loss in mice. Further exploration found that HKSA caused cellular senescence, telomere length shortening, and telomere dysfunction-induced foci (TIF) in limb bones. As a well-known Telomerase activator, cycloastragenol (CAG) significantly alleviated HKSA-induced telomere erosion and bone loss. These results suggested that telomere erosion in bone marrow cells is a possible mechanism of HKSA-induced bone loss. CAG may protect against HKSA-induced bone loss by alleviating telomere erosion in bone marrow cells.

Keywords

bone loss; chronic inflammation; heat-killed S. aureus (HKSA); senescence; telomere.

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