2. Academic Validation
  3. Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

  • Polymers (Basel). 2023 Feb 25;15(5):1160. doi: 10.3390/polym15051160.
Mahsa Sedighi 1 2,  Neha Shrestha 3 4,  Zahra Mahmoudi 5,  Zahra Khademi 6,  Alireza Ghasempour 7,  Hamideh Dehghan 7,  Seyedeh Fahimeh Talebi 7,  Maryam Toolabi 8,  Véronique Préat 3,  Bozhi Chen 9 10,  Xindong Guo 9 10,  Mohammad-Ali Shahbazi 8 11
Affiliations

Affiliations

  • 1 Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Birjand University of Medical Sciences, Birjand 9717853076, Iran.
  • 2 Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand 9717853076, Iran.
  • 3 Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université Catholique de Louvain, 1200 Brussels, Belgium.
  • 4 Department of Biomedicine and Translational Research, Research Institute for Bioscience and Biotechnology, Kathmandu P.O. Box 7731, Nepal.
  • 5 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan 6517838636, Iran.
  • 6 Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177948954, Iran.
  • 7 Student Research Committee, Birjand University of Medical Sciences, Birjand 9717853076, Iran.
  • 8 Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • 9 State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China.
  • 10 Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
  • 11 W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
PMID: 36904404 DOI: 10.3390/polym15051160
Abstract

Self-assembly is a growth mechanism in nature to apply local interactions forming a minimum energy structure. Currently, self-assembled Materials are considered for biomedical applications due to their pleasant features, including scalability, versatility, simplicity, and inexpensiveness. Self-assembled Peptides can be applied to design and fabricate different structures, such as micelles, hydrogels, and vesicles, by diverse physical interactions between specific building blocks. Among them, bioactivity, biocompatibility, and biodegradability of peptide hydrogels have introduced them as versatile platforms in biomedical applications, such as Drug Delivery, tissue engineering, biosensing, and treating different diseases. Moreover, Peptides are capable of mimicking the microenvironment of natural tissues and responding to internal and external stimuli for triggered drug release. In the current review, the unique characteristics of peptide hydrogels and recent advances in their design, fabrication, as well as chemical, physical, and biological properties are presented. Additionally, recent developments of these biomaterials are discussed with a particular focus on their biomedical applications in targeted Drug Delivery and gene delivery, stem cell therapy, Cancer therapy and immune regulation, bioimaging, and regenerative medicine.

Keywords

biocompatibility; biodegradability; biomedical applications; peptide-based hydrogels; self-assembly.

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