2. Academic Validation
  3. MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation

MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation

  • Nat Immunol. 2023 Mar 16. doi: 10.1038/s41590-023-01468-3.
Domien Vanneste # 1 2,  Qiang Bai # 1 2,  Shakir Hasan # 1 2 3,  Wen Peng 1 2,  Dimitri Pirottin 2 4,  Joey Schyns 1 2,  Pauline Maréchal 1 2,  Cecilia Ruscitti 1 2,  Margot Meunier 1 2,  Zhaoyuan Liu 5,  Céline Legrand 4,  Laurence Fievez 2 4,  Florent Ginhoux 5 6 7 8,  Coraline Radermecker 1 2,  Fabrice Bureau 4,  Thomas Marichal 9 10 11
Affiliations

Affiliations

  • 1 Laboratory of Immunophysiology, GIGA Institute, Liège University, Liège, Belgium.
  • 2 Faculty of Veterinary Medicine, Liège University, Liège, Belgium.
  • 3 Department of Immunology, University of Toronto, Toronto, Canada.
  • 4 Laboratory of Cellular and Molecular Immunology, GIGA Institute, Liège University, Liège, Belgium.
  • 5 Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China.
  • 6 Inserm U1015, Gustave Roussy, Bâtiment de Médecine Moléculaire, Villejuif, France.
  • 7 Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
  • 8 Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore.
  • 9 Laboratory of Immunophysiology, GIGA Institute, Liège University, Liège, Belgium. t.marichal@uliege.be.
  • 10 Faculty of Veterinary Medicine, Liège University, Liège, Belgium. t.marichal@uliege.be.
  • 11 Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium. t.marichal@uliege.be.
  • # Contributed equally.
PMID: 36928411 DOI: 10.1038/s41590-023-01468-3
Abstract

Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation from monocytes or on RTM self-renewal. Here, we used a mouse model of inducible lung interstitial macrophage (IM) niche depletion and refilling to investigate the development of IMs in vivo. Using time-course single-cell RNA-sequencing analyses, bone marrow chimeras and gene targeting, we found that engrafted Ly6C+ classical monocytes proliferated locally in a Csf1 receptor-dependent manner before differentiating into IMs. The transition from monocyte proliferation toward IM subset specification was controlled by the transcription factor MafB, while c-Maf specifically regulated the identity of the CD206+ IM subset. Our data provide evidence that, in the mononuclear phagocyte system, the ability to proliferate is not merely restricted to myeloid progenitor cells and mature RTMs but is also a tightly regulated capability of monocytes developing into RTMs in vivo.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z