2. Academic Validation
  3. Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice

Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice

  • Genome Biol. 2023 Apr 6;24(1):67. doi: 10.1186/s13059-023-02918-9.
Wencheng Zhu # 1 2,  Yufeng Ding # 1,  Juan Meng # 1 3,  Lei Gu # 4,  Wenjun Liu # 1 3,  Li Li 1,  Hongyu Chen 1,  Yining Wang 1,  Ziyi Li 5,  Chen Li 6,  Yidi Sun 7 8,  Zhen Liu 9 10
Affiliations

Affiliations

  • 1 Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
  • 2 Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China.
  • 3 University of Chinese Academy of Sciences, Beijing, China.
  • 4 Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • 5 Shanghai Applied Protein Technology Co., Ltd., Shanghai, China.
  • 6 Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. cli@shsmu.edu.cn.
  • 7 Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, China. ydsun@ion.ac.cn.
  • 8 Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China. ydsun@ion.ac.cn.
  • 9 Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, China. zliu2010@ion.ac.cn.
  • 10 Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China. zliu2010@ion.ac.cn.
  • # Contributed equally.
PMID: 37024923 DOI: 10.1186/s13059-023-02918-9
Abstract

N6-methyladenosine (m6A) modification has been shown to regulate RNA metabolism. Here, we investigate m6A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m6A can be maternally inherited or de novo gained after fertilization. Interestingly, m6A modification on maternal mRNAs not only correlates with mRNA degradation, but also maintains the stability of a small group of mRNAs thereby promoting their translation after fertilization. We identify Ythdc1 and Ythdf2 as key m6A readers for mouse preimplantation development. Our study reveals a key role of m6A mediated RNA metabolism during MZT in mammals.

Keywords

Maternal-to-zygotic transition; Multi-omics; Ythdc1; Ythdf2; m6A landscape.

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