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  3. Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics

Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics

  • Mol Cell. 2023 May 18;83(10):1544-1546. doi: 10.1016/j.molcel.2023.04.028.
Billy Wai-Lung Ng 1,  Tongyang Xu 2,  Zhihao Guo 2
Affiliations

Affiliations

  • 1 School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address: billyng@cuhk.edu.hk.
  • 2 School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
PMID: 37207621 DOI: 10.1016/j.molcel.2023.04.028
Abstract

Most human proteins lack small-molecule ligands, rendering these proteins "undruggable." In this issue of Molecular Cell, Lazear et al.1 develop a novel chemical proteomic screening platform and discover new chemical probes targeting previously undruggable protein complexes.

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  • HY-158301
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