2. Academic Validation
  3. IFITM3 restricts RABV infection through inhibiting viral entry and mTORC1- dependent autophagy

IFITM3 restricts RABV infection through inhibiting viral entry and mTORC1- dependent autophagy

  • Vet Microbiol. 2023 Jun 28;284:109823. doi: 10.1016/j.vetmic.2023.109823.
Jiaqi Ma 1,  Zhongzhong Tu 2,  Shouwen Du 3,  Xinying Zhang 2,  Jie Wang 4,  Jianxiong Guo 2,  Ye Feng 2,  Hongbin He 5,  Hongmei Wang 5,  Chang Li 6,  Changchun Tu 7,  Yan Liu 8
Affiliations

Affiliations

  • 1 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China; Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
  • 2 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • 3 Department of infectious diseases, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China.
  • 4 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China; Engineering Research Center of Glycoconjugates of Ministry of Education, Jinlin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University, Changchun 130024, China.
  • 5 Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
  • 6 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address: lichang78@163.com.
  • 7 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address: changchun_tu@hotmail.com.
  • 8 Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address: liu820512@163.com.
PMID: 37392666 DOI: 10.1016/j.vetmic.2023.109823
Abstract

Rabies, which caused by rabies virus (RABV), is a zoonotic and life-threatening disease with 100% mortality, and there is no effective treatment thus far due to the unclear pathogenesis and less of treatment targets. Interferon-induced transmembrane protein 3 (IFITM3) has recently been identified as an important anti-viral host effector induced by type I interferon. However, the role of IFITM3 in RABV Infection has not been elucidated. In this study, we demonstrated that IFITM3 is a crucial restriction factor for RABV, the viral-induced IFITM3 significantly inhibited RABV replication, while knockdown of IFITM3 had the opposite effect. We then identified that IFNβ induces the upregulation of IFITM3 in the absence or presence of RABV Infection, meanwhile, IFITM3 positively regulates RABV-triggered production of IFNβ in a feedback manner. In-depth research we found that IFITM3 not only inhibits the virus absorb and entry, but also inhibits viral replication through mTORC1-dependent Autophagy. All these findings broaden our understanding of IFITM3 function and uncover a novel mechanism against RABV Infection.

Keywords

Anti-viral effect; Autophagy; IFITM3; IFNβ; RABV.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z