2. Academic Validation
  3. Rapid, green disulphide bond formation in water using the corrin dicyanocobinamide

Rapid, green disulphide bond formation in water using the corrin dicyanocobinamide

  • Chem Commun (Camb). 2023 Aug 10;59(65):9836-9839. doi: 10.1039/d3cc02646a.
Alyssa Spear 1,  Oleksandr Orativskyi 1,  Samantha Tran 1,  Jon A Zubieta 1,  Robert P Doyle 1 2 3
Affiliations

Affiliations

  • 1 Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA. rpdoyle@syr.edu.
  • 2 Department of Medicine, State University of New York Upstate Medical University, Syracuse, New York, USA.
  • 3 Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York, USA.
PMID: 37525990 DOI: 10.1039/d3cc02646a
Abstract

Peptide chemists seek rapid methods combined with facile purification when producing disulphide bonds post solid-phase synthesis. Current methods typically require long reaction times of up to two days, can result in side-products from over-oxidation and/or degradation, require organic solvents, and/or require challenging purification. Herein, we describe a rapid, green, and facile oxidation of a series of Peptides with up to three disulphide bonds. The method was conducted in aqueous solution, in air, utilizing the biocompatible corrin ring-containing compound dicyanocobinamide, and offers reaction times under 1 hour with simple one step removal of the catalyst.

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