2. Academic Validation
  3. Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue

Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue

  • Eur J Pharmacol. 2023 Aug 1;175942. doi: 10.1016/j.ejphar.2023.175942.
Ling Yang 1,  Linzi Li 1,  Qian Lu 1,  Lingfeng Li 1,  Chun Xie 1,  Fakun Jiang 1,  Hongbing Li 2,  Ai Zhao 3,  Qian Wang 4,  Wenyong Xiong 5
Affiliations

Affiliations

  • 1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, PR China.
  • 2 Herb Biotechnology (Yunnan) Co. LTD, Kunming 650500, PR China.
  • 3 Sanqi Medical College, Wenshan University, Wenshan 663099, PR China. Electronic address: 80610867@qq.com.
  • 4 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, PR China. Electronic address: 20210209@ynu.edu.cn.
  • 5 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Pharmacy, Yunnan University, Kunming 650500, PR China. Electronic address: xwy@ynu.edu.cn.
PMID: 37536624 DOI: 10.1016/j.ejphar.2023.175942
Abstract

As a global epidemic disease, obesity causes dysfunction of glucose and lipid metabolism leading to persistently high morbidity and mortality. Given the difficulty to achieve and maintain weight loss through controlling diet and physical exercise, pharmacotherapy is considered an effective treatment for obesity. This investigation revealed that alisol B, a triterpene monomer isolated from the classical Chinese medicine Alisma orientale (Sam.) Juzep, functioned in suppressing adipogenesis and reducing the mass of subcutaneous adipose tissue, resulting in the reduction of weight gain, and improvements of hyperglycemia, hyperlipidemia, and Insulin resistance in HFD-induced obese mice. In consistent to the results, alisol B also significantly inhibited adipocyte differentiation and maturation in vitro. Furthermore, our data revealed that the effects of alisol B on adipogenesis were mediated by LKB1-AMPK signaling pathway. In total, alisol B could be a potential lead compound which contributes to the improvement of obesity-related metabolic disorders.

Keywords

AMPK; Adipocyte differentiation; Alisol B; LKB1; Obesity.

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