2. Academic Validation
  3. Autophagy induced by human adenovirus B7 structural protein VI inhibits viral replication

Autophagy induced by human adenovirus B7 structural protein VI inhibits viral replication

  • Virol Sin. 2023 Aug 5;S1995-820X(23)00100-1. doi: 10.1016/j.virs.2023.08.002.
Linlin Zhang 1,  Yali Duan 2,  Wei Wang 3,  Qi Li 1,  Jiao Tian 1,  Yun Zhu 1,  Ran Wang 1,  Zhengde Xie 4
Affiliations

Affiliations

  • 1 Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China; Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, 100045, China.
  • 2 Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China; Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, 100045, China; Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
  • 3 Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China; Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, 100045, China; Beijing Coal Group General Hospital, Beijing, 100045, China.
  • 4 Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China; Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, 100045, China. Electronic address: xiezhengde@bch.com.cn.
PMID: 37549881 DOI: 10.1016/j.virs.2023.08.002
Abstract

Human adenovirus-B7 (HAdV-B7) causes severe acute lower respiratory tract infections in children. None of the child-specific Antiviral drugs and vaccine against HAdV-B7 is available currently, and the pathogenesis is unclear. Autophagy, as part of innate immunity, plays an important role in resistance to viral Infection by degrading the virus and promoting the development of innate and adaptive immunity. This study provided evidence that HAdV-B7 Infection induced complete autophagic flux, and the pharmacological induction of Autophagy decreased HAdV-B7 replication. In this process, the host protein Bcl2-associated athanogene 3 (BAG3) mediated Autophagy to inhibit the replication of HAdV-B7 by binding to the PPSY structural domain of viral protein pVI through its WW structural domain. These findings further our understanding of the host immune response during viral Infection and will help to develop broad anti-HAdV therapies.

Keywords

Autophagy; Bcl2-associated athanogene 3 (BAG3); Human adenovirus B7 (HAdV-B7); Virus replication.

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