Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation

Affiliations

• 1 Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, South Korea.
• 2 Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, South Korea; Department of HY-KIST Bio-convergence, Hanyang University, Seoul 04763, South Korea.
• 3 Department of Chemistry and Integrative Institute of Basic Science, Soongsil University, Seoul 06978, South Korea.
• 4 Research Animal Resources Center, Research Resources Division, Korea Institute of Science and Technology, Seoul 02792, South Korea.
• 5 Department of Chemistry, Pusan National University, Busan 46241, South Korea.
• 6 Department of Molecular Science and Technology, Ajou University, Suwon 16499, South Korea.
• 7 Department of Chemistry & Biochemistry, University of California at Los Angeles (UCLA), Los Angeles, CA 90095-1569, USA.
• 8 Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, CA 90095, USA.
• 9 Department of Pathology, College of Medicine, Hanyang University, Seoul 04763, South Korea.
• 10 Department of Chemistry and Integrative Institute of Basic Science, Soongsil University, Seoul 06978, South Korea. Electronic address: jhkim19@ssu.ac.kr.
• 11 Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, South Korea; Department of HY-KIST Bio-convergence, Hanyang University, Seoul 04763, South Korea. Electronic address: slee19@kist.re.kr.