2. Cell Cycle/DNA Damage Autophagy Epigenetics
  3. Autophagy HDAC
  4. HDAC-IN-62

HDAC-IN-62 (Compound 5) 一种 HDAC 抑制剂，对 HDAC6/8/11 的 IC50 分别为 0.78、1.0、1.2μM。HDAC-IN-62 通过启动自噬 (Autophagy) 来抑制诱导的小胶质细胞活化，并抑制一氧化氮的产生。HDAC-IN-62 具有抗炎和抗抑郁作用。HDAC-IN-62 抑制小鼠大脑中的小胶质细胞激活。

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HDAC-IN-62 Chemical Structure

HDAC-IN-62 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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HDAC-IN-62 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-62 (Compound 5) a HDAC inhibitor, with IC50s of 0.78, 1.0, 1.2? μM for HDAC6/8/11 respectively. HDAC-IN-62 inhibits-induced microglial activation by the initiation of autophagy, and inhibits nitric oxide production. HDAC-IN-62 has anti-inflammatory and anti-depressant effects. HDAC-IN-62 inhibits microglial activation in mouse brain[1].

IC50 & Target

0.78, 1.0, 1.2? μM for HDAC6/8/11[1]
分子量

302.35

Formula

C15H14N2O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-62 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-62AutophagyHDACHistone deacetylasesmicroglialanti-inflammatoryanti-depressantnitric oxideInhibitorinhibitorinhibit

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产品名称：
HDAC-IN-62
目录号：
HY-155182
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