Heteroantigen-assembled nanovaccine enhances the polyfunctionality of TILs against tumor growth and metastasis

Affiliations

• 1 Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College; Kunming, Yunnan, 650000, China; State Key Laboratory of Reproductive Medicine, Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Hospital, Nanjing Medical University; Nanjing 211166, China; Department of Immunology, Key Laboratory of Immunological Environment and Disease, Key Laboratory of Human Functional Genomics of Jiangsu Province, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Gusu School, Nanjing Medical University; Nanjing 211166, China; Department of Epidemiology, National Vaccine Innovation Platform, Center for Global Health, Nanjing Medical University, Nanjing, China; Department of Central Laboratory, The Affiliated Huai'an N0.1 People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
• 2 Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College; Kunming, Yunnan, 650000, China.
• 3 State Key Laboratory of Reproductive Medicine, Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Hospital, Nanjing Medical University; Nanjing 211166, China; Department of Immunology, Key Laboratory of Immunological Environment and Disease, Key Laboratory of Human Functional Genomics of Jiangsu Province, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Gusu School, Nanjing Medical University; Nanjing 211166, China; Department of Epidemiology, National Vaccine Innovation Platform, Center for Global Health, Nanjing Medical University, Nanjing, China; Department of Central Laboratory, The Affiliated Huai'an N0.1 People's Hospital, Nanjing Medical University, Huai'an, 223300, China.
• 4 CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China. Electronic address: wanghao@nanoctr.cn.
• 5 Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College; Kunming, Yunnan, 650000, China; State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, 100190, China; Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, 100190, China. Electronic address: liuye@imbcams.com.cn.
• 6 State Key Laboratory of Reproductive Medicine, Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Hospital, Nanjing Medical University; Nanjing 211166, China; Department of Immunology, Key Laboratory of Immunological Environment and Disease, Key Laboratory of Human Functional Genomics of Jiangsu Province, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Gusu School, Nanjing Medical University; Nanjing 211166, China; Department of Epidemiology, National Vaccine Innovation Platform, Center for Global Health, Nanjing Medical University, Nanjing, China; Department of Central Laboratory, The Affiliated Huai'an N0.1 People's Hospital, Nanjing Medical University, Huai'an, 223300, China. Electronic address: chenyun@njmu.edu.cn.