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  3. Aminooxyacetic acid hemihydrochloride leads to decreased intracellular ATP levels and altered cell cycle of prostate cancer cells by suppressing energy metabolism

Aminooxyacetic acid hemihydrochloride leads to decreased intracellular ATP levels and altered cell cycle of prostate cancer cells by suppressing energy metabolism

  • Biomed Pharmacother. 2023 Oct 4:167:115605. doi: 10.1016/j.biopha.2023.115605.
Hailong Teng 1,  Biao Yang 1,  Yuangang Su 1,  Junchun Chen 1,  Lei Cui 1,  Ran Sun 1,  Jinmin Zhao 2,  Qian Liu 3,  An Qin 4
Affiliations

Affiliations

  • 1 Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China.
  • 2 Guangxi Key Laboratory of Regenerative Medicine, Orthopaedic Department, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
  • 3 Guangxi Key Laboratory of Regenerative Medicine, Orthopaedic Department, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China. Electronic address: liuqian@gxmu.edu.cn.
  • 4 Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, China; Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: dr_qinan@163.com.
PMID: 37801901 DOI: 10.1016/j.biopha.2023.115605
Abstract

The second most common Cancer among men is prostate Cancer, which is also the fifth leading reason for male Cancer deaths worldwide. Bone metastases are the main factor affecting the prognosis of prostate Cancer. Consequently, antitumor and anti-prostate cancer-induced bone destruction medicines are urgently needed. We previously discovered that aminooxyacetic acid hemihydrochloride (AOAA) suppressed bone resorption and osteoclast growth by decreasing adenosine triphosphate (ATP) production and limiting Oxidative Phosphorylation (OXPHOS). Here, we evaluated the impacts of AOAA on prostate Cancer RM-1 cells in vitro. It's found that AOAA significantly inhibited cell proliferation, migration, and invasiveness, decreased ATP levels, increased ROS, halted the cell cycle phase, and triggered Apoptosis. AOAA also decreased mitochondrial membrane potential and the ability to uptake glucose, suggesting that the antitumor effects of AOAA were expressed through the inhibition of OXPHOS and glycolysis. Furthermore, we assessed the effects of AOAA in vivo using a prostate cancer-induced bone osteolysis mice model. AOAA also delayed tumor growth and bone destruction in vivo. On the whole, our findings imply that AOAA may potentially have therapeutic effects on prostate Cancer and prostate cancer-induced osteolysis.

Keywords

Aminooxyacetic acid hemihydrochloride; Apoptosis; Cell cycle; Energy metabolism; Prostate cancer; Reactive oxygen species.

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