2. Academic Validation
  3. Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model

Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model

  • Cancers (Basel). 2023 Sep 22;15(19):4681. doi: 10.3390/cancers15194681.
Min Hee Yang 1,  Mina Lee 2,  Amudha Deivasigamani 3,  Duc Dat Le 2,  Chakrabhavi Dhananjaya Mohan 4,  Kam Man Hui 3,  Gautam Sethi 5,  Kwang Seok Ahn 1
Affiliations

Affiliations

  • 1 Department of Science in Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
  • 2 College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon-si 57922, Republic of Korea.
  • 3 Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore 169610, Singapore.
  • 4 FEST Division, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.
  • 5 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
PMID: 37835375 DOI: 10.3390/cancers15194681
Abstract

DA, one of the medium-chain fatty acids found in coconut oil, is suggested to have diverse biochemical functions. However, its possible role as a chemoprevention agent in HCC has not been deciphered. Aberrant activation of c-Met can modulate tumor growth and progression in HCC. Here, we report that DA exhibited pro-found anti-tumor effects on human HCC through the suppression of HGF/c-Met signaling cascades in vitro and in vivo. It was noted that DA inhibited HGF-induced activation of c-Met and its downstream signals. DA induced apoptotic cell death and inhibited the expression of diverse tumorigenic proteins. In addition, DA attenuated tumor growth and lung metastasis in the HCC mouse model. Similar to in vitro studies, DA also suppressed the expression of c-Met and its downstream signals in mice tissues. These results highlight the substantial potential of DA in the prevention and treatment of HCC.

Keywords

c-Met; capric acid; hepatocellular carcinoma; orthotopic mouse model.

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