2. Academic Validation
  3. Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway

Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway

  • Biomed Pharmacother. 2024 Jan 9:171:116110. doi: 10.1016/j.biopha.2023.116110.
Tao Liu 1,  Shan Zhu 1,  Yi Yang 1,  Wenxiao Qin 1,  Zijing Wang 1,  Zhiyue Zhao 1,  Tao Liu 1,  Xiang Wang 1,  Tian Duan 1,  Yang Liu 2,  Yan Liu 3,  Qingmei Xia 2,  Han Zhang 4,  Nan Li 5
Affiliations

Affiliations

  • 1 Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR China.
  • 2 Chinese medical college,Tianjin University of Traditional Chinese Medicine, Tianjin, PR China.
  • 3 Tianjin Polytechnic University, Tianjin, PR China.
  • 4 Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR China. Electronic address: zhanghan0023@126.com.
  • 5 Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China; Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional chinese Medicine, Tianjin, PR China; Engineering research center of Modern chinese Medicine Discovery and Preparation Technique, Ministry of education, Tianjin University of Traditional chinese Medicine, Tianjin, PR China. Electronic address: linan@tjutcm.edu.cn.
PMID: 38198955 DOI: 10.1016/j.biopha.2023.116110
Abstract

Skin is susceptible to premature aging in response to ultraviolet (UV) radiation-induced oxidative stress, which can ultimately result in aberrant aging or age-related disorders. Accordingly, strategies that can be adopted to mitigate oxidative stress may contribute to protecting skin from induced aging-related damage, thereby offering promising approaches for the treatment of skin diseases and disorders. In this regard, oroxylin A (OA), a natural flavonoid isolated from certain Plants used in traditional Chinese medicine, is considered to have notable antioxidant, anti-inflammatory, and anti-apoptotic properties, and is often used to treat certain inflammatory diseases. To date, however, there has been comparatively little research on the effects of OA with respect skin aging. In this study, we utilized UV radiation-induced mouse and cellular models of aging to assess the efficacy of OA in protecting against skin aging. Subsequently, to elucidate the potential mechanisms underlying the protective effect of OA on skin aging, we performed molecular docking analysis to investigate the involvement of the Anti-aging gene SIRT1, which was further confirmed on the basis of SIRT1 gene silencing. We accordingly demonstrated that by promoting an increase in the expression of SIRT1, OA can contribute to suppressing UV-induced skin photo-aging in cells/mice by reducing oxidative stress. Furthermore, we established that by activating SIRT1, OA can also promote the dissociation of Nrf2 from Keap1 and its subsequent nuclear translocation. Collectively, our findings in this study reveal OA to be an effective natural compound that can be administered to delay the aging of skin triggered by UV, both in vivo and in vitro, by binding to SIRT1 to promote the deacetylation and nuclear translocation of Nrf2, thereby contributing to a reduction in oxidative stress. These findings may this provide a therapeutic target for the prevention of skin aging or aging-induced skin diseases.

Keywords

Acetylation; Natural compound; Nrf2; Oroxylin A; Oxidative stress; Sirt1.

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