2. Academic Validation
  3. The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato

The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato

  • Mol Plant. 2024 Feb 9:S1674-2052(24)00043-1. doi: 10.1016/j.molp.2024.02.006.
Shaofang Wu 1,  Chaoyi Hu 2,  Changan Zhu 1,  Yanfen Fan 3,  Jie Zhou 1,  Xiaojia Xia 1,  Kai Shi 1,  Yanhong Zhou 1,  Christine H Foyer 4,  Jingquan Yu 5
Affiliations

Affiliations

  • 1 Department of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China.
  • 2 Department of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China; Hainan Institute, Zhejiang University, Yazhou Bay Science and Technology City, Sanya 572025, China.
  • 3 Department of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China; College of Horticulture, Northwest Agriculture & Forestry University, Xianyang 712100, China.
  • 4 School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston B15 2TT, UK.
  • 5 Department of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China; Hainan Institute, Zhejiang University, Yazhou Bay Science and Technology City, Sanya 572025, China; Key Laboratory of Horticultural Plants Growth and Development, Agricultural Ministry of China, Zhejiang University, Hangzhou 310058, China. Electronic address: jqyu@zju.edu.cn.
PMID: 38341757 DOI: 10.1016/j.molp.2024.02.006
Abstract

Jasmonates (JAs), a class of lipid-derived stress Hormones, play a crucial role across an array of plant physiological processes and stress responses. Although JA signaling is thought to rely predominantly on the degradation of specific JAZ proteins by SCFCOI1, it remains unclear whether Other pathways are involved in the regulation of JAZ protein stability. Here, we report that PUB22, a plant U-box type E3 ubiquitin Ligase, plays a critical role in the regulation of plant resistance against Helicoverpa armigera and Other JA responses in tomato. Whereas COI1 physically interacts with JAZ1/2/5/7, PUB22 physically interacts with JAZ1/3/4/6. PUB22 ubiquitinates JAZ4 to promote its degradation via the 26S Proteasome pathway. Importantly, we observed that pub22 mutants showreduced resistance to H. armigera, whereas jaz4 single mutants and jaz1 jaz3 jaz4 jaz6 quadruple mutants have enhanced resistance. The hypersensitivity of pub22 mutants to herbivores could be partially rescued by JAZ4 mutation. Moreover, we found that expression of PUB22 can be transcriptionally activated by MYC2, thus forming a positive feedback circuit in JA signaling. We noticed that the PUB22-JAZ4 module also regulates Other JA responses, including defense against B. cinerea, inhibition of root elongation, and anthocyanin accumulation. Taken together, these results indicate that PUB22 plays a crucial role in plant growth and defense responses, together with COI1-regulated JA signaling, by targeting specific JAZs.

Keywords

COI1; JA signaling; JAZ; MYC2; PUB22; Solanum lycopersicum.

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