2. Academic Validation
  3. Glycocalyx-Mimicking Nanoparticles with Differential Organ Selectivity for Drug Delivery and Therapy

Glycocalyx-Mimicking Nanoparticles with Differential Organ Selectivity for Drug Delivery and Therapy

  • Adv Mater. 2024 Mar 15:e2311283. doi: 10.1002/adma.202311283.
Dohyeon Kim 1 2,  Chang-Hee Whang 1 2,  Jungwoo Hong 3 4,  Monica Celine Prayogo 1 2,  Wonsik Jung 1 2,  Seojung Lee 1 2,  Hocheol Shin 1 2,  Yujin Kim 1 2,  Jiyoung Yu 5 6,  Min Joong Kim 5 6,  Kyunggon Kim 5 6,  Hee-Seung Lee 3 4,  Sangyong Jon 1 2
Affiliations

Affiliations

  • 1 Department of Biological Sciences, KAIST Institute of BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
  • 2 Center for Precision Bio-Nanomedicine, KAIST, 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
  • 3 Department of Chemistry, KAIST, 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
  • 4 Center for Multiscale Chiral Architectures (CMCA), KAIST, 291 Daehak-ro, Daejeon, 34141, Republic of Korea.
  • 5 Department of Convergence Medicine, Asan Medical Center, 88, Olympic-ro, Seoul, 05505, Republic of Korea.
  • 6 Department of Digital Medicine, College of Medicine, University of Ulsan, 88, Olympic-ro, Seoul, 05505, Republic of Korea.
PMID: 38489768 DOI: 10.1002/adma.202311283
Abstract

Organ-selective Drug Delivery is expected to maximize the efficacy of various therapeutic modalities while minimizing their systemic toxicity. Lipid nanoparticles and polymersomes can direct the organ-selective delivery of mRNAs or gene editing machineries, but their delivery is limited to mostly liver, spleen, and lung. A platform that enables delivery to these and other target organs is urgently needed. Here, a library of glycocalyx-mimicking nanoparticles (GlyNPs) comprising five randomly combined sugar moieties is generated, and direct in vivo library screening is used to identify GlyNPs with preferential biodistribution in liver, spleen, lung, kidneys, heart, and brain. Each organ-targeting GlyNP hit show cellular tropism within the organ. Liver, kidney, and spleen-targeting GlyNP hits equipped with therapeutics effectively can alleviate the symptoms of acetaminophen-induced liver injury, cisplatin-induced kidney injury, and immune thrombocytopenia in mice, respectively. Furthermore, the differential organ targeting of GlyNP hits is influenced not by the protein corona but by the sugar moieties displayed on their surface. It is envisioned that the GlyNP-based platform may enable the organ- and cell-targeted delivery of therapeutic cargoes.

Keywords

bilirubin; bilirubin nanoparticles; drug delivery; glycocalyx; glyconanoparticles; organ tropism.

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