2. Academic Validation
  3. Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress

Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress

  • Bioorg Chem. 2024 Jun:147:107369. doi: 10.1016/j.bioorg.2024.107369.
Lingzhi Wang 1,  Wenxi Li 2,  Yinggang Li 2,  Gengrui Chen 2,  Lijuan Zhao 2,  Wu Li 2,  Shengwei Wang 2,  Chunming Wang 3,  Yanxian Feng 4,  Yibo Zhang 5
Affiliations

Affiliations

  • 1 School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China; Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, National Engineering Research Center of Genetic Medicine, Guangzhou, China.
  • 2 School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.
  • 3 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China.
  • 4 School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China. Electronic address: yanxianfeng@wyu.edu.cn.
  • 5 Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, National Engineering Research Center of Genetic Medicine, Guangzhou, China. Electronic address: zyb_87@hotmail.com.
PMID: 38640721 DOI: 10.1016/j.bioorg.2024.107369
Abstract

Non-alcoholic fatty liver disease (NAFLD) is a complex pathogenic metabolic syndrome characterized by increased inflammation and endoplasmic reticulum stress. In recent years, natural Polysaccharides derived from traditional Chinese medicine have shown significant anti-inflammatory effects, making them an attractive therapeutic option. However, little research has been conducted on the therapeutic potential of dried tangerine peel polysaccharide (DTPP) - one of the most important medicinal resources in China. The results of the present study showed that DTPP substantially reduced macrophage infiltration in vivo and suppressed the expression of pro-inflammatory factors and endoplasmic reticulum stress-related genes. Additionally, surface plasmon resonance analysis revealed that DTPP had a specific affinity to myeloid differentiation factor 2, which consequently suppressed lipopolysaccharide-induced inflammation via interaction with the Toll-like Receptor 4 signaling pathway. This study provides a potential molecular mechanism underlying the anti-inflammatory effects of DTPP on NAFLD and suggests DTPP as a promising therapeutic strategy for NAFLD treatment.

Keywords

Dried tangerine peel polysaccharide; Endoplasmic reticulum stress; Inflammation; NAFLD; Zebrafish.

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