2. Academic Validation
  3. THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma

THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma

  • FEBS Lett. 2024 Apr 25. doi: 10.1002/1873-3468.14889.
Zi-Hao Wang 1,  Jingyi Wang 2 3,  Fuchen Liu 4,  Sijun Sun 2 5,  Quan Zheng 6,  Xiaotian Hu 5,  Zihan Yin 2 3,  Chengmei Xie 2,  Haiyan Wang 3,  Tianshi Wang 7,  Shengjie Zhang 2,  Yi-Ping Wang 1 2
Affiliations

Affiliations

  • 1 Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • 2 Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.
  • 3 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.
  • 4 The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital, Naval Medical University, Shanghai, China.
  • 5 Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.
  • 6 Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, China.
  • 7 Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, China.
PMID: 38664231 DOI: 10.1002/1873-3468.14889
Abstract

Mitochondria harbor the Oxidative Phosphorylation (OXPHOS) system to sustain cellular respiration. However, the transcriptional regulation of OXPHOS remains largely unexplored. Through the Cancer genome atlas (TCGA) transcriptome analysis, transcription factor THAP domain-containing 3 (THAP3) was found to be strongly associated with OXPHOS gene expression. Mechanistically, THAP3 recruited the Histone Methyltransferase SET and MYND domain-containing protein 3 (SMYD3) to upregulate H3K4me3 and promote OXPHOS gene expression. The levels of THAP3 and SMYD3 were altered by metabolic cues. They collaboratively supported liver Cancer cell proliferation and colony formation. In clinical human liver Cancer, both of them were overexpressed. THAP3 positively correlated with OXPHOS gene expression. Together, THAP3 cooperates with SMYD3 to epigenetically upregulate cellular respiration and liver Cancer cell proliferation.

Keywords

SET and MYND domain‐containing protein 3; THAP domain‐containing 3; histone H3 lysine 4 tri‐methylation; liver cancer; mitochondrial respiration; oxidative phosphorylation.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z