2. Academic Validation
  3. The promising antioxidant effects of lignans: Nrf2 activation comes into view

The promising antioxidant effects of lignans: Nrf2 activation comes into view

  • Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep;397(9):6439-6458. doi: 10.1007/s00210-024-03102-x.
Emad H M Hassanein 1,  Hanan S Althagafy 2,  Mohammad A Baraka 3,  Esraa K Abd-Alhameed 4,  Islam M Ibrahim 4,  Mostafa S Abd El-Maksoud 4,  Nesma M Mohamed 5 6,  Samir A Ross 7 8
Affiliations

Affiliations

  • 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
  • 2 Department of Biochemistry, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
  • 3 Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
  • 4 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
  • 5 Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt. nesma.mohamed269@pharm.aun.edu.eg.
  • 6 Department of Pharmacognosy, Faculty of Pharmacy, Badr University in Assiut, Assiut, 77771, Egypt. nesma.mohamed269@pharm.aun.edu.eg.
  • 7 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.
  • 8 Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
PMID: 38695909 DOI: 10.1007/s00210-024-03102-x
Abstract

Lignans are biologically active compounds widely distributed, recognized, and identified in seeds, fruits, and vegetables. Lignans have several intriguing bioactivities, including anti-inflammatory, antioxidant, and Anticancer activities. Nrf2 controls the expression of many cytoprotective genes. Activation of Nrf2 is a promising therapeutic approach for treating and preventing diseases resulting from oxidative injury and inflammation. Lignans have been demonstrated to stimulate Nrf2 signaling in a variety of in vitro and experimental animal models. The review summarizes the findings of fourteen Lignans (Schisandrin A, Schisandrin B, Schisandrian C, Magnolol, Honokiol, Sesamin, Sesamol, Sauchinone, Pinoresinol, Phyllanthin, Nectandrin B, Isoeucommin A, Arctigenin, Lariciresinol) as antioxidative and anti-inflammatory agents, affirming how Nrf2 activation affects their pharmacological effects. Therefore, Lignans may offer therapeutic candidates for the treatment and prevention of various diseases and may contribute to the development of effective Nrf2 modulators.

Keywords

Antioxidant; Inflammation; Lignans; Nrf2/ARE; Phytochemicals.

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