2. Academic Validation
  3. Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization

Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization

  • Cell Rep. 2024 May 18;43(6):114246. doi: 10.1016/j.celrep.2024.114246.
Ningjie Yang 1,  Yang Sun 1,  Bing Han 1,  Na Deng 1,  Gaizhen Li 1,  Qian Han 1,  Yinan Wang 1,  Han Cai 1,  Fan Liu 2,  Bin Cao 1,  Wenbo Deng 1,  Haili Bao 3,  Shuangbo Kong 4,  Jinhua Lu 5,  Haibin Wang 6
Affiliations

Affiliations

  • 1 Fujian Provincial Key Laboratory of Reproductive Health Research, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
  • 2 Fujian Provincial Key Laboratory of Reproductive Health Research, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
  • 3 Fujian Provincial Key Laboratory of Reproductive Health Research, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: christina200512@sina.com.
  • 4 Fujian Provincial Key Laboratory of Reproductive Health Research, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: shuangbo_kong@163.com.
  • 5 Fujian Provincial Key Laboratory of Reproductive Health Research, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: jinhua888@126.com.
  • 6 Fujian Provincial Key Laboratory of Reproductive Health Research, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: haibin.wang@vip.163.com.
PMID: 38762885 DOI: 10.1016/j.celrep.2024.114246
Abstract

The decidua plays a crucial role in providing structural and trophic support to the developing conceptus before placentation. Following embryo attachment, embryonic components intimately interact with the decidual tissue. While evidence indicates the participation of embryo-derived factors in crosstalk with the uterus, the extent of their impact on post-implantation decidual development requires further investigation. Here, we utilize transgenic mouse models to selectively eliminate primary trophoblast giant cells (pTGCs), the embryonic cells that interface with maternal tissue at the forefront. pTGC ablation impairs decidualization and compromises decidual interferon response and lipid metabolism. Mechanistically, pTGCs release factors such as interferon kappa (IFNK) to strengthen the decidual interferon response and lipoprotein Lipase (LPL) to enhance lipid accumulation within the decidua, thereby promoting decidualization. This study presents genetic and metabolomic evidence reinforcing the proactive role of pTGC-derived factors in mobilizing maternal resources to strengthen decidualization, facilitating the normal progression of early pregnancy.

Keywords

CP: Developmental biology; CP: Metabolism; decidua; interferon response; lipid metabolism; maternal-embryonic interaction; trophoblast.

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