2. Academic Validation
  3. Microenvironment-Responsive Hydrogel Reduces Seizures After Traumatic Brain Injury in Juvenile Rats by Reducing Oxidative Stress and Hippocampal Inflammation

Microenvironment-Responsive Hydrogel Reduces Seizures After Traumatic Brain Injury in Juvenile Rats by Reducing Oxidative Stress and Hippocampal Inflammation

  • Macromol Biosci. 2024 May 29:e2400050. doi: 10.1002/mabi.202400050.
Zhengzhong Han 1 2,  Zeqi Zhao 2 3,  Hao Yu 4,  Lansheng Wang 2,  Chenglong Yue 1 2,  Bingxin Zhu 1 2,  Yongqi Zhu 1 2,  Zhengwei Li 1 2,  Zhuang Sha 5 6
Affiliations

Affiliations

  • 1 Department of Neurosurgery, Xuzhou Children's Hospital, No. 18 Sudi North Road, Quanshan District, Xuzhou, 221002, P. R. China.
  • 2 Clinical College, Xuzhou Medical University, No. 209 Tongshan Road, Xuzhou, 221002, P. R. China.
  • 3 Department of Otolaryngology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou, 221002, P. R. China.
  • 4 Pediatric Epilepsy Center, Peking University First Hospital, No. 5 Leyuan Road, Daxing District, Beijing, 102627, P. R. China.
  • 5 Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou, 221002, P. R. China.
  • 6 Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Tianjin Medical University General Hospital, Ministry of Education, 154 Anshan Road, Heping District, Tianjin, 300052, China.
PMID: 38810210 DOI: 10.1002/mabi.202400050
Abstract

Traumatic brain injury (TBI) is the primary cause of child mortality and disability worldwide. It can result in severe complications that significantly impact children's quality of life, including post-traumatic epilepsy (PTE). An increasing number of studies suggest that TBI-induced oxidative stress and neuroinflammatory sequelae (especially, inflammation in the hippocampus region) may lead to the development of PTE. Due to the blood-brain barrier (BBB), typical systemic pharmacological therapy for TBI cannot deliver berberine (BBR) to the targeted location in the early stages of the injury, although BBR has strong anti-inflammatory properties. To break through this limitation, a microenvironment-responsive gelatin methacrylate (GM) hydrogel to deliver poly(propylene sulfide)60 (PPS60) and BBR (GM/PB) is developed for regulating neuroinflammatory reactions and removing Reactive Oxygen Species (ROS) in the brain trauma microenvironment through PPS60. In situ injection of the GM/PB hydrogel efficiently bypasses the BBB and is administered directly to the surface of brain tissue. In post-traumatic brain injury models, GM/PB has the potential to mitigate oxidative stress and neuroinflammatory responses, facilitate functional recovery, and lessen seizing. These findings can lead to a new treatment for brain injuries, which minimizes complications and improves the quality of life.

Keywords

epilepsy; microenvironment‐responsive hydrogel; neuroinflammation; reactive oxygen species; traumatic brain injury.

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