2. Academic Validation
  3. Co-delivery of doxorubicin-dihydroartemisinin prodrug/TEPP-46 nano-liposomes for improving antitumor and decreasing cardiotoxicity in B16-F10 tumor-bearing mice

Co-delivery of doxorubicin-dihydroartemisinin prodrug/TEPP-46 nano-liposomes for improving antitumor and decreasing cardiotoxicity in B16-F10 tumor-bearing mice

  • Colloids Surf B Biointerfaces. 2024 May 26:241:113992. doi: 10.1016/j.colsurfb.2024.113992.
Qiuyue Jin 1,  Xiaohui Zhou 1,  Xiaomin Niu 1,  Canqi Ping 1,  Xiaozhou Dong 1,  Danyu Duan 1,  Rongrong Wang 1,  Yi Chen 1,  Fei Pan 1,  Fan Yang 1,  Xihua Yang 2,  Guoshun Zhang 1,  Ruili Wang 1,  Shuqiu Zhang 3,  Guolian Ren 4
Affiliations

Affiliations

  • 1 School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China.
  • 2 Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China.
  • 3 School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China; Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China; Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, Shanxi Medical University, Taiyuan 030001, China. Electronic address: shuqiu.zhang@126.com.
  • 4 School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China; Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China; Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, Shanxi Medical University, Taiyuan 030001, China. Electronic address: glren2007@126.com.
PMID: 38833960 DOI: 10.1016/j.colsurfb.2024.113992
Abstract

In order to reduce the cardiotoxicity of doxorubicin (DOX) and improve its antitumor effect, dihydroartemisinin (DHA) and DOX prodrug (DOX-S-DHA) synthesized via a single sulfur bond was used with TEPP-46 to prepare nano-liposomes (DOX-S-DHA@TEPP-46 Lips). In which, TEPP-46 was expected to exert p53 bidirectional regulation to promote the synergistic antitumor effect of DOX and DHA while reducing cardiotoxicity. DOX-S-DHA@TEPP-46 Lips exhibited uniform particle size, good stability, and excellent redox-responsive activity. DOX-S-DHA@TEPP-46 Lips could significantly inhibit the proliferation of tumor cells, but had less cytotoxicity on normal cells. The presence of TEPP-46 increased the content of p53 protein, which further induced tumor cell Apoptosis. DOX-S-DHA@TEPP-46 Lips had satisfactory long circulation to enhance the antitumor efficacy and reversed the cardiotoxicity of DOX in B16-F10 tumor-bearing mice. In conclusion, DOX-S-DHA@TEPP-46 Lips provides a new insight on creating sophisticated redox-sensitive nano-liposomes for Cancer therapy as well as the decreased cardiotoxicity of DOX.

Keywords

Antitumor; Dihydroartemisinin; Doxorubicin; Nano-liposome; TEPP-46.

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