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  3. A Light-Responsive Neural Circuit Suppresses Feeding

A Light-Responsive Neural Circuit Suppresses Feeding

  • J Neurosci. 2024 Jul 24;44(30):e2192232024. doi: 10.1523/JNEUROSCI.2192-23.2024.
Hailan Liu 1,  Na Qu 2 3 4 5 6,  Natalia Valdez Gonzalez 7,  Marco A Palma 7,  Huamin Chen 8 3 6,  Jiani Xiong 8 3 5,  Abhinav Choubey 9,  Yongxiang Li 10,  Xin Li 9,  Meng Yu 10,  Hesong Liu 10,  Longlong Tu 10,  Nan Zhang 10,  Na Yin 10,  Kristine Marie Conde 10,  Mengjie Wang 10,  Jonathan Carter Bean 10,  Junying Han 10,  Nikolas Anthony Scarcelli 10,  Yongjie Yang 10,  Kenji Saito 11,  Huxing Cui 11 12 13,  Qingchun Tong 14,  Zheng Sun 9,  Chunmei Wang 10,  Xing Cai 15,  Li Lu 15,  Yang He 10,  Yong Xu 1 16 17
Affiliations

Affiliations

  • 1 Department of Pediatrics, Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030 yongx@bcm.edu. hailan.liu@bcm.edu questina@163.com.
  • 2 Research Center for Mental Health and Neuroscience, Wuhan Mental Health Center, Wuhan 430012, China yongx@bcm.edu. hailan.liu@bcm.edu questina@163.com.
  • 3 Wuhan Hospital for Psychotherapy, Wuhan 430012, China.
  • 4 Affiliated Wuhan Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430012, China.
  • 5 Research Center for Psychological and Health Sciences, China University of Geosciences, Wuhan 430012, China.
  • 6 Affiliated Wuhan Mental Health Center, Jianghan University, Wuhan 430012, China.
  • 7 Human Behavior Laboratory, Texas A&M University, College Station, Texas 77843.
  • 8 Research Center for Mental Health and Neuroscience, Wuhan Mental Health Center, Wuhan 430012, China.
  • 9 Department of Medicine-Endocrinology, Baylor College of Medicine, Houston, Texas 77030.
  • 10 Department of Pediatrics, Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030.
  • 11 Department of Pharmacology and Neuroscience, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242.
  • 12 Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242.
  • 13 F.O.E. Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242.
  • 14 Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030.
  • 15 Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China.
  • 16 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030.
  • 17 Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.
PMID: 38897723 DOI: 10.1523/JNEUROSCI.2192-23.2024
Abstract

LIGHT plays an essential role in a variety of physiological processes, including vision, mood, and glucose homeostasis. However, the intricate relationship between LIGHT and an animal's feeding behavior has remained elusive. Here, we found that LIGHT exposure suppresses food intake, whereas darkness amplifies it in male mice. Interestingly, this phenomenon extends its reach to diurnal male Nile grass rats and healthy humans. We further show that lateral habenula (LHb) neurons in mice respond to LIGHT exposure, which in turn activates 5-HT neurons in the dorsal Raphe nucleus (DRN). Activation of the LHb→5-HTDRN circuit in mice blunts darkness-induced hyperphagia, while inhibition of the circuit prevents light-induced anorexia. Together, we discovered a light-responsive neural circuit that relays the environmental LIGHT signals to regulate feeding behavior in mice.

Keywords

5-HT; LHb; feeding; light.

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