Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis

Affiliations

• 1 State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China. zhangdi@pku.edu.cn.
• 2 Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. zhangdi@pku.edu.cn.
• 3 Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
• 4 State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China.
• 5 Shenzhen Bay Laboratory, Shenzhen, China.
• 6 Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
• 7 State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.
• 8 Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
• 9 National Clinical Research Center for Geriatrics and General Practice Ward/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
• 10 Lewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Philadelphia, PA, USA.
• 11 Center for Biopharmaceuticals and Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• 12 School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
• 13 Research Center for Analytical Science and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, China.
• 14 Department of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota at Twin Cities, Minneapolis, MN, USA.
• 15 National Clinical Research Center for Geriatrics and General Practice Ward/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. lunzhi.dai@scu.edu.cn.
• 16 Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA. lingjun.li@wisc.edu.
• 17 School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA. lingjun.li@wisc.edu.
• 18 Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA. yingming.zhao@uchicago.edu.
• # Contributed equally.