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  3. Doramectin attenuates inflammation, obesity and insulin resistance in food-borne obese mice

Doramectin attenuates inflammation, obesity and insulin resistance in food-borne obese mice

  • Biochem Biophys Res Commun. 2024 Jul 14:732:150404. doi: 10.1016/j.bbrc.2024.150404.
Tianrong Jin 1,  Jialin Jia 2,  Wenhua Li 2,  Pengfei Wu 3,  Tingting Liu 2,  Bangwei Luo 4,  Zhiren Zhang 5
Affiliations

Affiliations

  • 1 Medical College of Chongqing University, 131 Yubei Road, Shapingba District, Chongqing, 400030, China.
  • 2 Institute of Immunology, Third Military Medical University, 30 Gaotanyan Main Street, Chongqing, 400038, China.
  • 3 Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, 83 Xinqiao Main Street, Chongqing, 400037, China.
  • 4 Institute of Immunology, Third Military Medical University, 30 Gaotanyan Main Street, Chongqing, 400038, China. Electronic address: luo6341@tmmu.edu.cn.
  • 5 Institute of Immunology, Third Military Medical University, 30 Gaotanyan Main Street, Chongqing, 400038, China. Electronic address: zhangzhiren@tmmu.edu.cn.
PMID: 39033553 DOI: 10.1016/j.bbrc.2024.150404
Abstract

The avermectin derivative doramectin is widely used clinically as an antiparasitic drug and, in addition, doramectin may have a modulatory role in obesity. Adipose tissue macrophage recruitment and polarization play an important role in obesity-induced inflammation and Insulin resistance. The aim of this study was to investigate the effects of doramectin on high-fat diet-induced inflammation and macrophage polarization in white adipose tissue of epididymis of obese mice. We found that compared with high-fat diet-fed obese mice, doramectin treatment resulted in a significant decrease in body weight and lipid levels, improved Insulin resistance, an increase in the proportion of M2-type macrophages and a decrease in the proportion of M1-type macrophages in the epididymal white adipose tissues, as well as a decrease in the infiltration of inflammatory cells in the adipose tissues. Thus, doramectin can ameliorate high-fat diet-induced obesity and adipose inflammation by affecting macrophage polarization in white adipose tissue.

Keywords

Adipose tissue; Doramectin; Insulin resistance; Macrophage polarization; Obesity.

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