2. Academic Validation
  3. Caffeic acid inhibits the tumorigenicity of triple-negative breast cancer cells through the FOXO1/FIS pathway

Caffeic acid inhibits the tumorigenicity of triple-negative breast cancer cells through the FOXO1/FIS pathway

  • Biomed Pharmacother. 2024 Sep:178:117158. doi: 10.1016/j.biopha.2024.117158.
Chufei Xie 1,  Liujia Chan 2,  Yuheng Pang 3,  Yuefeng Shang 3,  Weifang Cao 4,  Marmar Tuohan 2,  Qian Deng 2,  Yuji Wang 5,  Lichun Zhao 6,  Wenjing Wang 7
Affiliations

Affiliations

  • 1 College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, 4, Dongqing Road, Huaxi District, Guiyang 550025, China.
  • 2 Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, 10, Xitoutiao, Right Anmen West, Fengtai District, Beijing 100069, China.
  • 3 Department of Breast Surgery, Tumor Hospital of Harbin Medical University, 150, Haping Road, Nangang District, Harbin, Heilongjiang 150086, China.
  • 4 Institute of Basic Medicine, Chinese Academy of Medical Science, 5, Third Dongdan Alley, Dongcheng District, Beijing 100000, China.
  • 5 Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, 10, Xitoutiao, Right Anmen West, Fengtai District, Beijing 100069, China. Electronic address: wangyuji@ccmu.edu.cn.
  • 6 College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, 4, Dongqing Road, Huaxi District, Guiyang 550025, China; Science Experimental Center, Guangxi University of Traditional Chinese Medicine, 13, Wuhe Avenue, Qingxiu District, Nanning 530200, China. Electronic address: hyzlc@126.com.
  • 7 Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, 8, Xitoutiao, Right Anmen West, Fengtai District, Beijing 100069, China. Electronic address: wangwenjing85321@ccmu.edu.cn.
PMID: 39042963 DOI: 10.1016/j.biopha.2024.117158
Abstract

Triple-negative breast Cancer (TNBC) still one of the most challenging sub-type in breast Cancer clinical. Caffeic acid (CA) derived from effective components of traditional Chinese herbal medicine has been show potential against TNBCs. Our research has found that CA can inhibit the proliferation of TNBC cells while also suppressing the size of Cancer stem cell spheres. Additionally, it reduces Reactive Oxygen Species (ROS) levels and disruption of mitochondrial membrane potential. Simultaneously, CA influences the stemness of TNBC cells by reducing the expression of the stem cell marker protein CD44. Furthermore, we have observed that CA can modulate the FOXO1/FIS signaling pathway, disrupting mitochondrial function, inducing mitochondrial Autophagy, and exerting anti-tumor activity. Additionally, changes in the immune microenvironment were detected using a mass cytometer, we found that CA can induce M1 polarization of macrophages, enhancing anti-tumor immune responses to exert anti-tumor activity. In summary, CA can be considered as a lead compound for further research in targeting TNBC.

Keywords

Caffeic acid; FOXO1/FIS; Triple-negative breast cancer; mitochondrial autophagy; stemness; tumor microenvironment.

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