Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors

Affiliations

• 1 School of Molecular Sciences, Arizona State University, Tempe, AZ, USA.
• 2 Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, USA.
• 3 Biology Department, Brookhaven National Laboratory, Upton, NY, USA.
• 4 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
• 5 University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA, USA.
• 6 Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
• 7 Faculty of Pharmacy, Phenikaa University, Hanoi, Vietnam.
• 8 Curia Global, Albany, NY, USA.
• 9 Graduate School of Arts and Sciences, Boston University, Boston, MA, USA.
• 10 Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
• 11 Biodesign Center for Mechanism of Evolution, Arizona State University, Tempe, AZ, USA.
• 12 Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
• 13 Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA.
• 14 Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
• 15 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. tfchou@caltech.edu.
• 16 Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA. tfchou@caltech.edu.
• 17 School of Molecular Sciences, Arizona State University, Tempe, AZ, USA. plchiu@asu.edu.
• 18 Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, USA. plchiu@asu.edu.
• # Contributed equally.