2. Academic Validation
  3. Evaluation of aspartame effects at environmental concentration on early development of zebrafish: Morphology and transcriptome1

Evaluation of aspartame effects at environmental concentration on early development of zebrafish: Morphology and transcriptome1

  • Environ Pollut. 2024 Aug 23:361:124792. doi: 10.1016/j.envpol.2024.124792.
Yitian Wu 1,  Ziyuan Lin 2,  Feng Chen 2,  Xuan Zhang 1,  Yanyan Liu 3,  Huaqin Sun 4
Affiliations

Affiliations

  • 1 Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, China.
  • 2 SCU-CUHK Joint Laboratory for Reproductive Medicine, Zebrafish Research Platform, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, China.
  • 3 Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, China. Electronic address: liuyy39@qq.com.
  • 4 SCU-CUHK Joint Laboratory for Reproductive Medicine, Zebrafish Research Platform, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, China; Children's Medicine Key Laboratory of Sichuan Province, China. Electronic address: sunhuaqin@scu.edu.cn.
PMID: 39182820 DOI: 10.1016/j.envpol.2024.124792
Abstract

The use of aspartame as an artificial sweetener is prevalent in a wide range of everyday food products, potentially leading to health complications such as obesity, diabetes mellitus, autism spectrum disorders, and neurodegeneration. Aspartame has also been detected in natural water bodies at a concentration of 0.49 μg/L, yet research on its ecotoxicological effects on aquatic life remains scarce. This study aimed to investigate the potential negative effects of environmentally relevant concentrations of aspartame on the development of various tissues and organs in zebrafish embryos. We used a zebrafish model to treat embryos with aspartame at environmental concentration and those higher than in the environment-up to 1000 times. We observed that after exposure to aspartame body length increased, pigmentation was delayed, and neutrophil production inhibited in zebrafish. Furthermore, transcriptome analysis revealed that early exposure of zebrafish embryos to aspartame affected the transcriptomics of various systems, primarily by downregulating genes related to immune cell production, eye and optic nerve development, nervous system development, and growth hormone-related transcription. Most of the genes associated with Ferroptosis were upregulated. This study provides new insights into the ecotoxicological effects of aspartame on aquatic environments.

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