2. Academic Validation
  3. MAPK signaling pathway induced LOX-1+ polymorphonuclear myeloid-derived suppressor cells in biliary atresia

MAPK signaling pathway induced LOX-1+ polymorphonuclear myeloid-derived suppressor cells in biliary atresia

  • Clin Immunol. 2024 Sep 3:268:110355. doi: 10.1016/j.clim.2024.110355.
Cheng Chen 1,  Hezhen Wang 1,  Lili Xu 2,  Zhipeng Guo 1,  Ming Fu 1,  Huimin Xia 1,  Qiuming He 3,  Ruizhong Zhang 4,  Juan He 5
Affiliations

Affiliations

  • 1 Guangdong Provincial Key Laboratory of Research in Structure Birth Defect Disease and Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
  • 2 Clinical Laboratory, Guangzhou Red Cross Hospital, Jinan University, Guangzhou 510220, China.
  • 3 Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center Liuzhou Hospital, Liuzhou 545000, China; Department of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
  • 4 Guangdong Provincial Key Laboratory of Research in Structure Birth Defect Disease and Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China. Electronic address: zhangruizhong@gwcmc.org.
  • 5 Guangdong Provincial Key Laboratory of Research in Structure Birth Defect Disease and Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China. Electronic address: 2014689001@gzhmu.edu.cn.
PMID: 39237078 DOI: 10.1016/j.clim.2024.110355
Abstract

Biliary atresia (BA) is a severe pediatric liver disease characterized by progressive bile duct destruction and fibrosis, leading to significant liver damage and frequently necessitating liver transplantation. This study elucidates the role of LOX-1+ polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in BA pathogenesis and assesses their potential as non-invasive early diagnostic biomarkers. Using flow cytometry, immunofluorescence, and molecular profiling, we analyzed the expression and activity of these cells in peripheral blood and liver tissues from BA patients and controls. Our findings reveal a significant increase in the frequencies and function of LOX-1+PMN-MDSCs in BA patients, along with MAPK signaling pathway upregulation, indicating their involvement in disease mechanisms. Additionally, the frequencies of LOX-1+PMN-MDSC in peripheral blood significantly positively correlate with liver function parameters in BA patients, demonstrating diagnostic performance comparable to traditional serum markers. These findings suggest that LOX-1+PMN-MDSCs contribute to the immunosuppressive environment in BA and could serve as potential diagnostic targets.

Keywords

Biliary atresia; Lectin-type oxidized LDL receptor-1 (LOX-1); MAPK signaling pathway; Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC).

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