2. Academic Validation
  3. Effects of Mao tea from Nankun Mountain on nonalcoholic fatty liver disease in mice

Effects of Mao tea from Nankun Mountain on nonalcoholic fatty liver disease in mice

  • Food Funct. 2024 Sep 30;15(19):9863-9879. doi: 10.1039/d4fo01689k.
Weitao Zhang 1 2,  Lianshun Feng 1,  Peng Li 3,  Aoyi Wang 3,  Chunyan Dai 4,  Yajuan Qi 5,  Junfeng Lu 6,  Xiaojun Xu 2 7 8
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural Medicines, China Pharmaceutical University, 210009, Nanjing, Jiangsu, China.
  • 2 Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health) & School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. xiaojunxu2000@163.com.
  • 3 College of Basic Sciences, Shanxi Agricultural University, Jinzhong, China.
  • 4 Department of Pathology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
  • 5 School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China. yajuanqi@ncst.edu.cn.
  • 6 First Department of Liver Disease, Beijing You'An Hospital, Capital Medical University, Beijing 100069, China. junfengdoc@ccmu.edu.cn.
  • 7 Department of Pharmacy, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
  • 8 Center for Innovative Traditional Chinese Medicine Target and New Drug Research, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
PMID: 39246047 DOI: 10.1039/d4fo01689k
Abstract

Non-alcoholic fatty liver disease (NAFLD) poses a significant health threat due to its potential progression to liver fibrosis, cirrhosis, and even liver Cancer. Without proper management, NAFLD can lead to severe complications and significantly impact overall health and longevity. This study explores the potential anti-steatosis effects of Nankun Mountain Mao tea (MT) on hepatic lipid accumulation using both in vitro and in vivo models. In vitro experiments reveal that MT reduces lipid accumulation in hepatocytes and counteracts hepatic steatosis induced by palmitic acid and oleic acid. In vivo investigations on high-fat diet (HFD)-fed and high-fat, fructose, and Cholesterol (HFFC)-fed mice demonstrate that MT administration alleviates hepatic steatosis by reducing lipid accumulation, enhancing liver function, and mitigating inflammation. Transcriptomic analyses unveil the molecular mechanisms underlying the impact of MT on lipid metabolism and inflammation. It turns out that MT inhibits de novo lipid synthesis and NF-κB pathway against NAFLD. Furthermore, target prediction analysis identifies potential bioactive components group (BCG) within MT that may contribute to its anti-steatosis properties. Validation studies on primary hepatocytes confirm the effectiveness of these bioactive components in diminishing lipid accumulation and inflammation, suggesting their role in the therapeutic efficacy of MT against NAFLD.

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