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  3. The effects of arotinoids on rat mammary carcinogenesis

The effects of arotinoids on rat mammary carcinogenesis

  • Cancer Chemother Pharmacol. 1985;15(2):141-3. doi: 10.1007/BF00257524.
H R Hartmann,  W Bollag
PMID: 3926332 DOI: 10.1007/BF00257524
Abstract

The influence of two retinoids, Ro 13-6298, an arotinoid ethyl ester, and Ro 15-1570, an arotinoid ethyl sulfone, on rat mammary carcinogenesis was investigated. Mammary carcinomas were induced by oral administration of 15 mg dimethylbenz(a)anthracene (DMBA) to 50-day-old female Sprague-Dawley rats. Oral administration of the two retinoids significantly inhibited the development of tumors. The number and volume of mammary neoplasms were influenced in a dose-dependent manner.

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