2. Academic Validation
  3. Antiproliferative agent attenuates postthrombotic vein wall remodeling in murine and human subjects

Antiproliferative agent attenuates postthrombotic vein wall remodeling in murine and human subjects

  • J Thromb Haemost. 2024 Sep 30:S1538-7836(24)00559-2. doi: 10.1016/j.jtha.2024.09.012.
Hongji Pu 1,  Jiahao Lei 1,  Guodong Du 1,  Qun Huang 1,  Peng Qiu 1,  Junchao Liu 1,  Chenshu Li 2,  Xiaoliang Ying 2,  Kailang Liu 2,  Zhijue Xu 3,  Xinwu Lu 4,  Ruihua Wang 5
Affiliations

Affiliations

  • 1 Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
  • 2 Chuzhou First People's Hospital, the Affiliated Chuzhou Hospital of Anhui Medical University, Hefei, China.
  • 3 Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China; Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: xuzhijue@sjtu.edu.cn.
  • 4 Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Electronic address: luxinwu@shsmu.edu.cn.
  • 5 Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Electronic address: wangruihua0330@sina.com.
PMID: 39357567 DOI: 10.1016/j.jtha.2024.09.012
Abstract

Background: Despite appropriate treatment, up to 50% of patients with proximal deep vein thrombosis will develop postthrombotic syndrome (PTS). Once PTS occurs, there is no specific treatment, and some patients constantly experience intolerable symptoms. Hence, prevention of PTS is important.

Objectives: To characterize vein wall remodeling after thrombus and investigate the effects of antiproliferative agent on postthrombotic vein wall remodeling in murine and human subjects.

Methods: Features of postthrombotic vein wall remodeling in murine and human subjects were characterized using imaging and histologic examinations. Paclitaxel-loaded hydrogels were used to assess the effects of antiproliferative agent on the remodeling in murine model. Based on the abovementioned results, a pilot study was conducted to assess the effects of paclitaxel-coated balloon dilation in patients with severe PTS experiencing intolerable symptoms. The control cohort was obtained by 1:1 propensity score matching from a prospective database.

Results: Structural and functional alterations in postthrombotic vein wall were verified by imaging and histologic examinations, and predominant active α-smooth muscle actin-positive cells and fibroblast-specific protein 1-positive cells proliferation was observed. In the murine model, the application of paclitaxel-loaded hydrogels inhibited the remodeling. In the pilot clinical study, patients receiving drug-coated balloon demonstrated benefits in Villalta scores and venous clinical severity scores compared with those not receiving drug-coated balloon, and no severe adverse events were reported except for thrombosis recurrence.

Conclusion: Cell proliferation plays an important role in postthrombotic vein wall remodeling. Inhibition of cell proliferation inhibits the remodeling in murine model and may reduce signs and symptoms in patients with severe PTS.

Keywords

cell proliferation; postthrombotic syndrome; vascular remodeling; venous thrombosis.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z