2. Academic Validation
  3. CD36-mediated arachidonic acid influx from decidual stromal cells increases inflammatory macrophages in miscarriage

CD36-mediated arachidonic acid influx from decidual stromal cells increases inflammatory macrophages in miscarriage

  • Cell Rep. 2024 Oct 19;43(11):114881. doi: 10.1016/j.celrep.2024.114881.
Jiajia Chen 1,  Tingxuan Yin 1,  Xianyang Hu 1,  Lingyu Chang 1,  Yifei Sang 1,  Ling Xu 1,  Weijie Zhao 1,  Lu Liu 1,  Chunfang Xu 1,  Yikong Lin 1,  Yue Li 1,  Qingyu Wu 2,  Dajin Li 3,  Yanhong Li 4,  Meirong Du 5
Affiliations

Affiliations

  • 1 Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, Shanghai 200032, China.
  • 2 Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215031, China.
  • 3 Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, Shanghai 200032, China. Electronic address: djli@shmu.edu.cn.
  • 4 Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, Shanghai 200032, China. Electronic address: yanhongli@fudan.edu.cn.
  • 5 Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, Shanghai 200032, China; Department of Obstetrics and Gynecology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200092, China; State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau 999078, China. Electronic address: mrdu@fudan.edu.cn.
PMID: 39427314 DOI: 10.1016/j.celrep.2024.114881
Abstract

Spontaneous abortion is associated with aberrant lipid metabolism, but the underlying mechanisms remain unclear. Here, we show that lipids are accumulated in decidual stromal cells (DSCs) and macrophages (dMφs) in women with miscarriage and mouse abortion-prone models. Moreover, we show that excessive lipids from DSCs are transferred to dMφs via a CD36-dependent mechanism that induces inflammation in dMφs. In particular, DSC-derived arachidonic acid (AA) is internalized by dMφs via CD36, which activates cyclooxygenase 2-dependent prostaglandin E2 production and interleukin (IL)-1β expression. In mice, AA injection induces miscarriage, whereas conditional knockout of Cd36 in dMφs ameliorates AA-induced embryo loss. Additionally, DSC-derived Prolactin (PRL) inhibits CD36-mediated lipid intake in dMφs, and PRL administration reduces embryo loss in pregnant mice treated with CD36+ Mφs. Our findings reveal a critical interplay between DSCs and dMφs in dysregulated lipid metabolism that may contribute to miscarriage, in which PRL may be harnessed as a therapeutic agent.

Keywords

CP: Developmental biology; CP: Immunology.

Figures
Products
Inhibitors & Agonists
Other Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z