2. Academic Validation
  3. TLR2/NF-κB signaling in macrophage/microglia mediated COVID-pain induced by SARS-CoV-2 envelope protein

TLR2/NF-κB signaling in macrophage/microglia mediated COVID-pain induced by SARS-CoV-2 envelope protein

  • iScience. 2024 Sep 24;27(10):111027. doi: 10.1016/j.isci.2024.111027.
Huan Cui 1,  Fengrun Sun 1,  Ning Yu 1,  Yan Cao 1,  Xue Wang 1 2,  Di Zhang 1 2,  Zhen Chen 1 2,  Naili Wang 1 2,  Bo Yuan 1,  Penghao Liu 3,  Wanru Duan 3,  Wenying Qiu 1 2,  Xiangsha Yin 1 2,  Chao Ma 1 2 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Joint Laboratory of Anesthesia and Pain, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, No.5 DongDanSanTiao, Dongcheng District, Beijing 100005, China.
  • 2 National Human Brain Bank for Development and Function, Beijing, China.
  • 3 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Laboratory of Spinal Cord Injury and Functional Reconstruction, China International Neuroscience Institute (CHINA-INI), Beijing, China.
  • 4 Chinese Institute for Brain Research, Beijing 102206, China.
PMID: 39435149 DOI: 10.1016/j.isci.2024.111027
Abstract

Pain has become a major symptom of long COVID-19 without effective therapy. Apart from viral Infection pathological process, SARS-CoV-2 membranal proteins (envelope [S2E], spike [S2S] and membrane [S2M]) also present pro-inflammatory feature independently. Here, we aim to uncover the neuroinflammatory mechanism of COVID-pain induced by SARS-CoV-2 membranal proteins. We detected the three proteins in both peripheral sensory ganglions and spinal dorsal horn of COVID-19 donors. After intradermal and intrathecal injection, only S2E triggered pain behaviors, accompanied with upregulated-phosphorylation nuclear factor kappa B (NF-κB), which was significantly attenuated by minocycline in mice. We further identified Toll-like Receptor 2 (TLR2) among TLRs as the target of S2E to evoke inflammatory responses leading to COVID-pain. This study identified the nociceptive effect of S2E through directly interacting with macrophage/microglia TLR2 and inducing the following NF-κB inflammatory storm. Clearing away S2E and inhibiting macrophage/microglia TLR2 served as perspective therapeutic strategies for COVID-19 pain.

Keywords

Cell biology; Health sciences; Immune response; Sensory neuroscience.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z